DataVXACS NanoPaper
journal article·2025-04-08

Leveraging Vitamin C to Augment Nanoenabled Photothermal Immunotherapy

Wuxian Deng, Yiyuan Wang, Junyu Wang, Yitan Su, Mingyang Li, Kun Qu, Yucai Wang, Min Li

ACS Nano· Volume 19· Issue 13
Publisher page
Source abstract

Abstract

Photothermal immunotherapy (PTI) is valuable for precise tumor targeting and immune activation. However, its efficacy is hindered by insufficient immune response, elevated antioxidant levels within tumor, and intrinsic tumor resistance mechanisms. This study introduces Vitamin C (VC), a widely available dietary nutrient, as an effective enhancer for PTI. High-dose VC induces oxidative imbalance in tumor cells, making them more susceptible to nanoenabled near-infrared-II photothermal therapy (NIR-II PTT) with the photosensitizer IR1080. The combination of VC and NIR-II PTT significantly amplifies antitumor immunity by upregulating CXCL16 expression and promoting CXCR6 + T cell infiltration. Clinical data reveal that higher CXCL16 and CXCR6 levels in human tumors correlate with improved survival and T cell infiltration, underscoring the translational potential of this approach. This study positions VC as a safe, accessible, and cost-effective dietary enhancer for PTI, reshaping the role of dietary nutrients in cancer therapy and offering a strategy for overcoming treatment resistance.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Vitamin C and Antioxidants Research · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine

University of Science and Technology of China

National Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of Life Sciences and Medicine

Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Institute of Health and Medicine

Hefei Comprehensive National Science Center

Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases

Funding

National Key Research and Development Program of China · Major Science and Technology Projects in Anhui Province · National Natural Science Foundation of China · Natural Science Foundation of Anhui Province · Anhui Provincial Key Research and Development Plan · Chinese Academy of Sciences · USTC Research Funds of the Double First-Class Initiative · Project of collaborative innovation for colleges of Anhui province

References (52)

Show source-provided references
1. 10.1038/s41571-020-0410-210.1038/s41571-020-0410-2 ↗
2. 10.1016/j.addr.2022.11431110.1016/j.addr.2022.114311 ↗
3. 10.1038/nrc367210.1038/nrc3672 ↗
4. 10.1038/s41571-022-00717-y10.1038/s41571-022-00717-y ↗
5. 10.1002/adma.20200806110.1002/adma.202008061 ↗
6. 10.1039/D0CS00215A10.1039/D0CS00215A ↗
7. 10.1002/adfm.20210073810.1002/adfm.202100738 ↗
8. 10.4161/auto.2539910.4161/auto.25399 ↗
9. 10.1126/sciadv.abc437310.1126/sciadv.abc4373 ↗
10. 10.1016/j.jconrel.2023.02.04010.1016/j.jconrel.2023.02.040 ↗
11. 10.1016/j.ccell.2020.06.00110.1016/j.ccell.2020.06.001 ↗
12. 10.1038/nrm365810.1038/nrm3658 ↗
13. 10.1056/NEJMra05011110.1056/NEJMra050111 ↗
14. 10.1186/s12943-023-01790-210.1186/s12943-023-01790-2 ↗
15. 10.1161/01.CIR.94.1.610.1161/01.CIR.94.1.6 ↗
16. 10.1161/01.CIR.97.22.222210.1161/01.CIR.97.22.2222 ↗
17. 10.1016/j.ccell.2018.07.01410.1016/j.ccell.2018.07.014 ↗
18. 10.1126/science.aad867110.1126/science.aad8671 ↗
19. 10.1126/scitranslmed.aay870710.1126/scitranslmed.aay8707 ↗
20. 10.1038/s41467-020-16243-310.1038/s41467-020-16243-3 ↗
21. 10.1038/s41423-019-0247-810.1038/s41423-019-0247-8 ↗
22. 10.1016/j.cardiores.2004.08.00610.1016/j.cardiores.2004.08.006 ↗
23. 10.3390/nu1205150110.3390/nu12051501 ↗
24. 10.1038/s41568-019-0135-710.1038/s41568-019-0135-7 ↗
25. 10.1021/acs.nanolett.3c0148410.1021/acs.nanolett.3c01484 ↗
26. 10.1039/D0CS00664E10.1039/D0CS00664E ↗
27. 10.1038/s41467-019-12771-910.1038/s41467-019-12771-9 ↗
28. 10.1186/1476-4598-13-20410.1186/1476-4598-13-204 ↗
29. 10.1038/s41392-023-01373-z10.1038/s41392-023-01373-z ↗
30. 10.1186/s40880-018-0309-910.1186/s40880-018-0309-9 ↗
31. 10.1016/j.molcel.2010.10.00610.1016/j.molcel.2010.10.006 ↗
32. 10.1002/sstr.20230013210.1002/sstr.202300132 ↗
33. 10.1016/j.ccr.2021.21433010.1016/j.ccr.2021.214330 ↗
34. 10.1016/j.molcel.2010.09.02310.1016/j.molcel.2010.09.023 ↗
35. 10.1021/acs.nanolett.1c0223810.1021/acs.nanolett.1c02238 ↗
36. 10.1073/pnas.161318711310.1073/pnas.1613187113 ↗
37. 10.1038/nri.2016.10710.1038/nri.2016.107 ↗
38. 10.1158/2159-8290.CD-18-036710.1158/2159-8290.CD-18-0367 ↗
39. 10.1158/2159-8290.CD-13-098510.1158/2159-8290.CD-13-0985 ↗
40. 10.1080/2162402X.2021.193380810.1080/2162402X.2021.1933808 ↗
41. 10.1038/s41467-019-09015-110.1038/s41467-019-09015-1 ↗
42. 10.1158/0008-5472.CAN-20-233910.1158/0008-5472.CAN-20-2339 ↗
43. 10.1016/j.celrep.2018.12.00210.1016/j.celrep.2018.12.002 ↗
44. 10.1016/j.cell.2021.07.01510.1016/j.cell.2021.07.015 ↗
45. 10.1038/nbt.408610.1038/nbt.4086 ↗
46. 10.1038/s41551-021-00737-610.1038/s41551-021-00737-6 ↗
47. 10.1016/j.immuni.2021.01.01210.1016/j.immuni.2021.01.012 ↗
48. 10.1093/nar/gkz43010.1093/nar/gkz430 ↗
49. 10.1038/s41467-020-14963-010.1038/s41467-020-14963-0 ↗
50. 10.1093/bioinformatics/bts63510.1093/bioinformatics/bts635 ↗
51. 10.1093/bioinformatics/btu63810.1093/bioinformatics/btu638 ↗
52. 10.1186/s13059-014-0550-810.1186/s13059-014-0550-8 ↗