Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer
Source abstract
Abstract
Tumor-stromal interactions and stromal heterogeneity in the tumor microenvironment are critical factors that influence the progression, metastasis, and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). Here, we used spatial transcriptome technology to profile the gene expression landscape of primary PDAC and liver metastatic PDAC after bioactive black phosphorus nanomaterial (bioactive BP) treatment using a murine model of PDAC ( LSL-Kras G12D /+; LSL-Trp53 R172H /+; and Pdx-1-Cre mice). Bioinformatic and biochemical analyses showed that bioactive BP contributes to the tumor-stromal interplay by suppressing cancer-associated fibroblast (CAF) activation. Our results showed that bioactive BP contributes to CAF heterogeneity by decreasing the amount of inflammatory CAFs and myofibroblastic CAFs, two CAF subpopulations. Our study demonstrates the influence of bioactive BP on tumor-stromal interactions and CAF heterogeneity and suggests bioactive BP as a potential PDAC treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Pancreatic and Hepatic Oncology Research · MicroRNA in disease regulation · Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Hepatobiliary Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China
Central Laboratory, Peking University Shenzhen Hospital, Shenzhen 518036, China
Department of Pathology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China
Department of Pharmacy, Shenzhen University General Hospital/Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China
Shenzhen Key Laboratory of Micro/Nano Biosensing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Department of Surgery, The First Dongguan Affiliated Hospital, Guangdong Medical University, No. 42 Jiaoping Road, Tangxia Town, Dongguan 523710, China
Funding
National Key Research and Development Program of China · Basic and Applied Basic Research Foundation of Guangdong Province · National Natural Science Foundation of China · Shenzhen Medical Research Fund
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