DataVXACS NanoPaper
journal article·2024-10-15

Innovative Oral Nano/Gene Delivery System Based on Engineered Modified Saccharomyces cerevisiae for Colorectal Cancer Therapy

Tianli Shen, Xuejun Sun, Shuanying Yang, Wei Wang, Zilu Chen, Yuyao Lin, Sihua Li, Hang Peng, Lizhong Zeng, Gan Li, Xuqi Li, Bo Wang, Jingya Ning, Haimei Wen, Bo Lei, Long Zhang

ACS Nano· Volume 18· Issue 41
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Source abstract

Abstract

The efficient delivery of RNA-based drugs to solid tumors remains a formidable obstacle. We aim to develop a safe and efficient oral drug delivery system compatible with RNA-based drugs that is urgently needed to overcome challenges such as enzymatic degradation and gastrointestinal barriers to facilitate effective treatment for treating colorectal cancer (CRC). To address these challenges, we utilized engineered modified Saccharomyces cerevisiae to evaluate the delivery efficacy of miR21-antagomir for treating CRC in preclinical mouse models, including adenomatosis polyposis coli mutant transgenic mice Apc Min/+ and in situ tumor-bearing mice. An orally deliverable gene delivery system, YS@NPs21, was designed. This gene delivery system demonstrated effectively suppressed tumor growth in both Apc Min/+ and in situ tumor-bearing mice models. This system exhibited tumor-targeting capability, effective inhibition of tumor growth, and low toxicity toward nontumor cells. Successful implementation of this innovative oral drug delivery system could offer a straightforward, safe, and RNA drug-compatible approach to CRC treatment, ultimately improving patient outcomes and reducing medical costs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Research and Treatments · RNA Interference and Gene Delivery · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of General Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China

Department of Plastic, Aesthetic and Maxillofacial Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China

Department of General Surgery, Shaanxi Provincial People’s Hospital of Xi’an Jiaotong University, Xi’an 710068, China

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

Funding

Xi'an Municipal Bureau of Science and Technology · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Shaanxi Province

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