journal article·2023-12-12

Controllably Self-Assembled Antibacterial Nanofibrils Based on Insect Cuticle Protein for Infectious Wound Healing

Qiuyu Gong, Bohao Liu, Fenghou Yuan, Runyi Tao, Yinjuan Huang, Xiaoyan Zeng, Xingzhuo Zhu, Yilong Zhao, Yanpeng Zhang, Mei Yang, Jizhao Wang, Tian Liu, Guangjian Zhang

ACS Nano· Volume 17· Issue 23
Publisher page

Abstract

Developing self-assembled biomedical materials based on insect proteins is highly desirable due to their advantages of green, rich, and sustainable characters as well as excellent biocompatibility, which has been rarely explored. Herein, salt-induced controllable self-assembly, antibacterial performance, and infectious wound healing performance of an insect cuticle protein ( Of CPH-2 ) originating from the Ostrinia furnacalis larva head capsule are investigated. Interestingly, the addition of salts could trigger the formation of beaded nanofibrils with uniform diameter, whose length highly depends on the salt concentration. Surprisingly, the Of CPH-2 nanofibrils not only could form functional films with broad-spectrum antibacterial abilities but also could promote infectious wound healing. More importantly, a possible wound healing mechanism was proposed, and it is the strong abilities of Of CPH-2 nanofibrils in promoting vascular formation and antibacterial activity that facilitate the process of infectious wound healing. Our exciting findings put forward instructive thoughts for developing innovative bioinspired materials based on insect proteins for wound healing and related biomedical fields.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Silk-based biomaterials and applications · Antimicrobial Peptides and Activities · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P. R. China

Key Laboratory of Enhanced Recovery After Surgery of Integrated Chinese and Western Medicine, Administration of Traditional Chinese Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P. R. China

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

School of Bioengineering, Dalian University of Technology, Dalian 116024, P. R. China

State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, P. R. China

Department of Laboratory Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P. R. China

Funding

Xi?an Jiaotong University · Qingdao University of Science and Technology · National Natural Science Foundation of China · Key Research and Development Projects of Shaanxi Province

References (51)

Show source-provided references
1. 10.1073/pnas.171695111510.1073/pnas.1716951115 ↗
2. 10.1073/pnas.111228810810.1073/pnas.1112288108 ↗
3. 10.1074/jbc.M114.61493310.1074/jbc.M114.614933 ↗
4. 10.1016/j.ibmb.2009.10.00710.1016/j.ibmb.2009.10.007 ↗
5. 10.1002/adma.20110405110.1002/adma.201104051 ↗
6. 10.1021/bm005652u10.1021/bm005652u ↗
7. 10.1021/acs.biomac.2c0026110.1021/acs.biomac.2c00261 ↗
8. 10.1038/s41596-021-00535-z10.1038/s41596-021-00535-z ↗
9. 10.1038/s41467-022-30462-w10.1038/s41467-022-30462-w ↗
10. 10.1126/sciadv.abj942410.1126/sciadv.abj9424 ↗
11. 10.1016/j.cej.2022.13849410.1016/j.cej.2022.138494 ↗
12. 10.1038/nbt87410.1038/nbt874 ↗
13. 10.1126/science.120596210.1126/science.1205962 ↗
14. 10.1186/s40580-021-00294-310.1186/s40580-021-00294-3 ↗
15. 10.1039/C6CS00542J10.1039/C6CS00542J ↗
16. 10.1126/science.107106310.1126/science.1071063 ↗
17. 10.1126/science.196219110.1126/science.1962191 ↗
18. 10.1016/j.biotechadv.2021.10783510.1016/j.biotechadv.2021.107835 ↗
19. 10.1038/s41570-020-0215-y10.1038/s41570-020-0215-y ↗
20. 10.1021/acs.biomac.2c0056210.1021/acs.biomac.2c00562 ↗
21. 10.1021/acsami.7b1853510.1021/acsami.7b18535 ↗
22. 10.1021/acsnano.9b0139210.1021/acsnano.9b01392 ↗
23. 10.1016/j.ygcen.2007.02.01810.1016/j.ygcen.2007.02.018 ↗
24. 10.1242/jeb.22219010.1242/jeb.222190 ↗
25. 10.1016/j.ibmb.2014.11.00410.1016/j.ibmb.2014.11.004 ↗
26. 10.3390/insects1310095810.3390/insects13100958 ↗
27. 10.1021/acsnano.2c0675910.1021/acsnano.2c06759 ↗
28. 10.1021/acsnano.1c0295710.1021/acsnano.1c02957 ↗
29. 10.1016/j.jsb.2006.12.01010.1016/j.jsb.2006.12.010 ↗
30. 10.1016/j.jcis.2020.03.07510.1016/j.jcis.2020.03.075 ↗
31. 10.1021/acsnano.9b0344410.1021/acsnano.9b03444 ↗
32. 10.1016/j.cplett.2011.10.01110.1016/j.cplett.2011.10.011 ↗
33. 10.1007/s00018-021-03784-z10.1007/s00018-021-03784-z ↗
34. 10.1038/nrmicro.2016.9410.1038/nrmicro.2016.94 ↗
35. 10.1016/j.mimet.2022.10665610.1016/j.mimet.2022.106656 ↗
36. 10.1016/j.apsb.2021.07.01410.1016/j.apsb.2021.07.014 ↗
37. 10.1038/s42003-021-02137-710.1038/s42003-021-02137-7 ↗
38. 10.1021/bi991892m10.1021/bi991892m ↗
39. 10.1016/j.hazadv.2021.10000210.1016/j.hazadv.2021.100002 ↗
40. 10.1021/acs.jmedchem.1c0061410.1021/acs.jmedchem.1c00614 ↗
41. 10.1007/s11274-022-03227-210.1007/s11274-022-03227-2 ↗
42. 10.3389/fmicb.2020.0114610.3389/fmicb.2020.01146 ↗
43. 10.1021/acs.jmedchem.2c0202110.1021/acs.jmedchem.2c02021 ↗
44. 10.3390/bioengineering805006310.3390/bioengineering8050063 ↗
45. 10.1002/advs.20220690010.1002/advs.202206900 ↗
46. 10.1684/ecn.2009.015510.1684/ecn.2009.0155 ↗
47. 10.1093/brain/awh48910.1093/brain/awh489 ↗
48. 10.4049/jimmunol.120342110.4049/jimmunol.1203421 ↗
49. 10.1177/03946320110240030110.1177/039463201102400301 ↗
50. 10.1016/B978-0-12-802576-5.00007-310.1016/B978-0-12-802576-5.00007-3 ↗
51. 10.1016/j.ibmb.2011.09.00110.1016/j.ibmb.2011.09.001 ↗