DataVXACS NanoPaper
journal article·2023-03-14

An ER-Horse Detonating Stress Cascade for Hepatocellular Carcinoma Nanotherapy

Xintong Bian, Ningke Fan, Meng Li, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song, Siqiao Li, Wei Cheng

ACS Nano· Volume 17· Issue 5
Publisher page
Source abstract

Abstract

Persisting and excessive endoplasmic reticulum stress (ERS) can evoke rapid cell apoptosis. Therapeutic interference of ERS signaling holds enormous potential for cancer nanotherapy. Herein, a hepatocellular carcinoma (HCC) cell-derived ER vesicle (ERV) encapsulating siGRP94, denoted as ER-horse, has been developed for precise HCC nanotherapy. Briefly, ER-horse, like the Trojan horse, was recognized via homotypic camouflage, imitated the physiological function of ER, and exogenously opened the Ca 2+ channel. Consequently, the mandatory pouring-in of extracellular Ca 2+ triggered the aggravated stress cascade (ERS and oxidative stress) and apoptosis pathway with the inhibition of unfolded protein response by siGRP94. Collectively, our findings provide a paradigm for potent HCC nanotherapy via ERS signaling interference and exploring therapeutic interference of physiological signal transduction pathways for precision cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Endoplasmic Reticulum Stress and Disease · Autophagy in Disease and Therapy · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China

Molecular Medicine and Cancer Research Center, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

The Second Affliated Hospital of Chongqing Medical University, Chongqing 400010, China

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

Funding

Chongqing Municipal Key Laboratory of Institutions of Higher Education · Chongqing Municipal Education Commission · Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Chongqing · Chongqing Medical University · National Natural Science Foundation of China

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