DataVXACS NanoPaper
journal article·2023-06-27

SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy

Jannah Binte Mohamed Kamarudin, Bowen Sun, Aaron Song Chuan Foo, Xin-Yuan Lim, Heevah Judd, Xingfei Tan, Xuan Hao Tan, Rafhanah Banu Binte Abdul Razar, Min Liu, Jinglin Zhong, John Jia En Chua, Celene Wei Qi Ng, James C. H. Goh, Tuan Zea Tan, Bhav Harshad Parikh, Xinyi Su, Alan Prem Kumar, Wei Yi Ong, Naoki Yamaguchi, Sze Y. Set, George W. Yip, Yong Zhang, Daniel Boon Loong Teh

ACS Nano· Volume 17· Issue 12
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Source abstract

Abstract

Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy of irradiance and insufficient therapeutic depth. Here we report the design and preclinical validation of a flexible wireless upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable of large field, high intensity illumination for PDT of deep-seated tumors. The implant achieves this by incorporating submicrometer core–shell–shell NaYF 4 UCNPs into its design, which significantly enhances upconversion efficiency and mitigates light loss from surface quenching. We demonstrate the efficacy of SIRIUS UCNP implant mediated PDT in preclinical breast cancer disease models. In our in vitro experiments, SIRIUS directed 5-Aminolevulinic Acid (5-ALA) based wireless PDT leads to significant reactive oxygen species (ROS) generation and tumor apoptosis in hormonal receptor+/ HER2+ (MCF7) and triple-negative (MDA-MB-231) breast cancer cell lines. In our in vivo rodent model, SIRIUS-driven PDT is shown to be significant in regressing tumors when applied to orthotopically inoculated breast tumors. Following successful preclinical validation, we also describe a clinical prototype of UCNP breast implant with potential dual cosmetic and onco-therapeutic functions. SIRIUS is an upconversion breast implant for wireless PDT that fulfils all the design prerequisites necessary for seamless clinical translation.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Luminescence Properties of Advanced Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Department of Biomedical Engineering, College of Design & Engineering, National University of Singapore, Singapore, S117575

Division of Neurosurgery, Department of Surgery, National University Hospital, National University Health System, Singapore, S119074

MBBS Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Ngee Ann Polytechnic, Singapore, S599489

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, S138673

Neurobiology Program, Life Science Institute, National University of Singapore, Singapore, S117456

Division of General Surgery (Breast Surgery), Department of Surgery, National University Hospital, National University Health System, Singapore, S119074

Genomics and Data Analytics Core, Cancer Science Institute of Singapore, National University of Singapore, Singapore, S117599

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, S117597

Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, 153-8904, Japan

Funding

National Medical Research Council · Ministry of Education - Singapore · Institute for Health Innovation and Technology, National University of Singapore

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