journal article·2024-10-29

Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis

Rui Gao, Wei Zhang, Xiaoyong Chen, Junwu Shen, Yifei Qin, Yanyun Wang, Xueyan Wei, Wei Zou, Xiaoyi Jiang, Yingying Wang, Wanxin Huang, Haotian Chen, Zhenguang Li, Haiming Fan, Bin He, Yu Cheng

ACS Nano· Volume 18· Issue 43
Publisher page

Abstract

Magnetic nanorobots are emerging players in thrombolytic therapy due to their noninvasive remote actuation and drug loading capabilities. Although the nanorobots with a size under 100 nm are ideal to apply in microvascular systems, the propulsion performance of nanorobots is inevitably compromised due to the limited response to magnetic fields. Here, we demonstrate a nattokinase-loaded magnetic vortex nanorobot (NK-MNR) with an average size around 70 nm and high saturation magnetization for mechanical propelling and thermal responsive thrombolysis under a magnetic field with dual frequencies. The nanorobots are stable in suspension and undergo the magneto-steered assembly into chain-like NK-MNRs, which are regulated to generate magnetic forces to mechanically damage and penetrate the thrombus by the low-frequency rotating magnetic field. Synergistically, enhanced magnetic hyperthermia is triggered by an alternating magnetic field of high frequency, enabling heat-induced NK release and fibrinolysis. In this dual frequency-regulated magnetothrombolysis (fRMT) strategy, nanorobots collaborate under the dual magnetic energy conversion model to achieve the vasculature recanalization rate of 81.0% in thrombotic mice. Overall, the nanorobot with the special magnetic vortex property and multimodel controls is a promising nanoplatform for in vivo focalized microvascular thrombolysis.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Micro and Nano Robotics · Electrohydrodynamics and Fluid Dynamics · Photoreceptor and optogenetics research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine

Tongji University

Department of Control Science and Engineering

The National Key Laboratory of Autonomous Intelligent Unmanned Systems

The Frontiers Science Center for Intelligent Autonomous Systems

Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science

Northwest University

Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province

Funding

National Key Research and Development Program of China · Shanghai Municipal Education Commission · Science and Technology Commission of Shanghai Municipality · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Key Research and Development Projects of Shaanxi Province · Science and Technology Commission Foundation of Shanghai · Innovation Capability Support Program of Shaanxi

References (39)

Show source-provided references
1. 10.1016/S0140-6736(20)32658-110.1016/S0140-6736(20)32658-1 ↗
2. 10.1038/s41569-022-00787-610.1038/s41569-022-00787-6 ↗
3. 10.1056/NEJMoa161506610.1056/NEJMoa1615066 ↗
4. 10.1038/s41573-020-0061-010.1038/s41573-020-0061-0 ↗
5. 10.1126/sciadv.abf903310.1126/sciadv.abf9033 ↗
6. 10.1016/j.redox.2020.10150010.1016/j.redox.2020.101500 ↗
7. 10.1021/acsnano.2c1246310.1021/acsnano.2c12463 ↗
8. 10.1016/j.biomaterials.2020.12029710.1016/j.biomaterials.2020.120297 ↗
9. 10.1126/science.adh307310.1126/science.adh3073 ↗
10. 10.1126/scirobotics.aam643110.1126/scirobotics.aam6431 ↗
11. 10.1073/pnas.202318811810.1073/pnas.2023188118 ↗
12. 10.1002/advs.20190137810.1002/advs.201901378 ↗
13. 10.1126/sciadv.aaz820410.1126/sciadv.aaz8204 ↗
14. 10.1021/acsnano.8b0927710.1021/acsnano.8b09277 ↗
15. 10.1002/adma.20200036610.1002/adma.202000366 ↗
16. 10.1126/sciadv.adk897010.1126/sciadv.adk8970 ↗
17. 10.1038/s42256-022-00482-810.1038/s42256-022-00482-8 ↗
18. 10.1021/nn502995510.1021/nn5029955 ↗
19. 10.1021/acs.chemrev.0c0123410.1021/acs.chemrev.0c01234 ↗
20. 10.1002/adma.20200204710.1002/adma.202002047 ↗
21. 10.1126/scirobotics.abg990710.1126/scirobotics.abg9907 ↗
22. 10.1126/scirobotics.aav800610.1126/scirobotics.aav8006 ↗
23. 10.1126/sciadv.adg450110.1126/sciadv.adg4501 ↗
24. 10.1126/sciadv.adk725110.1126/sciadv.adk7251 ↗
25. 10.1002/adfm.20140435410.1002/adfm.201404354 ↗
26. 10.1002/advs.20200268210.1002/advs.202002682 ↗
27. 10.1021/acsnano.1c0736310.1021/acsnano.1c07363 ↗
28. 10.1016/j.tibtech.2023.06.00110.1016/j.tibtech.2023.06.001 ↗
29. 10.1039/C0NR00566E10.1039/C0NR00566E ↗
30. 10.1039/D0CS00309C10.1039/D0CS00309C ↗
31. 10.1017/S002211201000128X10.1017/S002211201000128X ↗
32. 10.1002/adma.20140503610.1002/adma.201405036 ↗
33. 10.1021/acsnano.9b0197910.1021/acsnano.9b01979 ↗
34. 10.1073/pnas.202209011810.1073/pnas.2022090118 ↗
35. 10.1002/advs.20180183710.1002/advs.201801837 ↗
36. 10.1021/acsami.8b0942310.1021/acsami.8b09423 ↗
37. 10.1063/1.351876410.1063/1.3518764 ↗
38. 10.1002/adhm.20190020310.1002/adhm.201900203 ↗
39. 10.1166/jbn.2020.2994162310.1166/jbn.2020.29941623 ↗