Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion
Source abstract
Abstract
Epidural adhesion or epidural fibrosis is the major reason for postoperative pain, which remains a clinically challenging problem. Current physical barriers fail to provide a satisfactory therapeutic outcome mainly due to their lack of adhesion, inability to prevent fluid leakage, and exhibiting limited antioxidant properties. Herein, we fabricated a cysteine-modified bioadhesive (SECAgel) with improved sealing and antioxidant properties for epidural adhesion prevention, inspired by the organism's antioxidant systems. The resulting SECAgel showed good injectability and in situ adhesion ability, effectively covering every corner of the irregular wound. Besides, it possessed efficient sealing properties (395.2 mmHg), effectively stopping blood leakage in the rabbit carotid artery transection model. The antioxidant experiments demonstrated that the SECAgel effectively scavenged various radicals and saved the cells from oxidative stress. Two animal models were used to show that the SECAgel effectively inhibited adhesion in both situations with and without cerebrospinal fluid leakage. The RNA sequencing analysis showed that SECAgel treatment effectively inhibited the expression of key genes related to adhesion development, inflammatory response, and oxidative stress. The SECAgel, together with good biocompatibility, can be a good candidate for preventing epidural adhesion in the clinic.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Anesthesia and Pain Management · Spine and Intervertebral Disc Pathology · Intestinal and Peritoneal Adhesions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China
Department of Burn/Plastic Surgery and Wound Repair, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Institute of Orthopedic Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China
Department of Dermatology, the Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, China
POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia-San Sebastián 20018, Spain
Department of Imaging Center, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China
School of Basic Medical Sciences, Institute of Molecular and Translational Medicine, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Funding
National Key Research and Development Program of China · Natural Science Basic Research Program of Shaanxi Province · National Natural Science Foundation of China · Strengthening Basic Disciplines Plan of Innovation Ability in Xi?an
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