journal article·2021-03-23Open access

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

Ali Yasin Sonay, Konstantinos Kalyviotis, Sine Yaganoglu, Aysen Unsal, Martina Konantz, Claire Teulon, Ingo Lieberwirth, Sandro Sieber, Shuai Jiang, Shahed Behzadi, Daniel Crespy, Katharina Landfester, Sylvie Roke, Claudia Lengerke, Periklis Pantazis

ACS Nano· Volume 15· Issue 3

Abstract

Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded in vivo without any long-term toxicological consequences to the organism. Here, we developed biodegradable harmonophores (bioharmonophores) that consist of polymer-encapsulated, self-assembling peptides that generate a strong SHG signal. When functionalized with tumor cell surface markers, these reporters can target single cancer cells with high detection sensitivity in zebrafish embryos in vivo. Thus, bioharmonophores will enable an innovative approach to cancer treatment using targeted high-resolution optical imaging for diagnostics and therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Lipid Membrane Structure and Behavior · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zurich, 4058 Basel, Switzerland

Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, U.K.

Department of Biomedicine, University Hospital Basel and University of Basel, 4031 Basel, Switzerland

Laboratory for Fundamental BioPhotonics, Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

Max Planck Institute for Polymer Research, 55128 Mainz, Germany

Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, 4031 Basel, Switzerland

Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 21210, Thailand

Institute of Materials Science and Engineering, School of Engineering, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

Lausanne Centre for Ultrafast Science, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

Division of Hematology, University Hospital Basel, 4031 Basel, Switzerland

Funding

Royal Society · FP7 People: Marie-Curie Actions · National Centre of Competence in Research Robotics · Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

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