journal article·2024-03-19

Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy

Fei Zeng, Yongchun Pan, Mengnan Wu, Qianglan Lu, Shurong Qin, Yanfeng Gao, Xiaowei Luan, Ruiyue Chen, Guanzhong He, Yuzhen Wang, Bangshun He, Zhaowei Chen, Yujun Song

ACS Nano· Volume 18· Issue 11
Publisher page

Abstract

Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-mineralization of autologous tumor cells with palladium ions in microfluidic droplets, which endowed the engineered cells with both immune and catalytic functions, to establish a bioorthogonally catalytic tumor whole-cell vaccine. This vaccine showed strong inhibition both in the occurrence and recurrence of tumor by invoking the immediate antitumor immunity and building a long-term immunity.
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Research context

OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · Monoclonal and Polyclonal Antibodies Research · Immunotherapy and Immune Responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China

College of Chemistry, Institute of Food Safety and Environment Monitoring, Fuzhou University, Fuzhou 350108, China

Key Laboratoty of Flexible Electronics& Institute of Advanced Materials, Nanjing Technology University, Nanjing 211816, China

Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Funding

State Key Laboratory of Analytical Chemistry for Life Sciences · Jiangsu Provincial Key Research and Development Program · National Key Research and Development Program of China · Natural Science Foundation of Jiangsu Province · High Level Innovation and Entrepreneurial Research Team Program in Jiangsu · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China

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