journal article·2023-12-12

Tetrahedral Framework Nuclear Acids Can Regulate Interleukin-17 Pathway to Alleviate Inflammation and Inhibit Heterotopic Ossification in Ankylosing Spondylitis

Lihang Wang, Yun Wang, Yang Jiang, Ming Chen, Zhuhai Li, Kai Wang, Chunshan Luo, Ning Ning, Jiancheng Zeng, Zongke Zhou, Yueming Song, Fan Yang, Shi-shu Huang, Yunfeng Lin

ACS Nano· Volume 17· Issue 23
Publisher page

Abstract

Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease that leads to serious spinal deformity and ankylosis. Persistent inflammation and progressive ankylosis lead to loss of spinal flexibility in patients with AS. Tetrahedral framework nucleic acids (tFNAs) have emerged as a one kind of nanomaterial composed of four specially designed complementary DNA single strands with outstanding biological properties. Results from in vivo experiments demonstrated that tFNAs treatment could inhibit inflammatory responses and heterotopic ossification to halt disease progression. In vitro, tFNAs were proved to influence the biological behavior of AS primary chondrocytes and inhibit the secretion of pro-inflammatory cytokines through interleukin-17 pathway. The osteogenic process of chondrocytes was as well inhibited at the transcriptional level to regulate the expression of related proteins. Therefore, we believe tFNAs had a strong therapeutic effect and could serve as a nonsurgical remedy in the future to help patients suffering from AS.
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Research context

OpenAlex topics: Spondyloarthritis Studies and Treatments · Bone and Joint Diseases · Eosinophilic Disorders and Syndromes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 GuoXue Road, Chengdu 610041, China

Department of Spine Surgery, Beijing Jishuitan Hospital Guizhou Hospital, No. 206 Sixian Road, Guiyang 550014, China

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14. 3rd Sec, Ren Min Nan Road, Chengdu 610041, China

The Second Affiliated Hospital of Chengdu Medical College, 416 Nuclear Industry Hospital, No. 4, North Section 4, Second Ring Road, Chengdu 610057, China

Department of Spine Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, No. 6 TaoYuan Road, Nanning 530016, China

The Brain Cognition & Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China

Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu, Sichuan 610041, China

Funding

West China Hospital, Sichuan University · West China School of Stomatology, Sichuan University · National Key Research and Development Program of China · Sichuan Province Youth Science and Technology Innovation Team · Science and Technology Department of Sichuan Province · Guizhou Provincial Science and Technology Department · National Natural Science Foundation of China · Sichuan Province Science and Technology Support Program

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