journal article·2023-04-25

Enhanced Proliferation of Visualizable Mesenchymal Stem Cell–Platelet Hybrid Cell for Versatile Intracerebral Hemorrhage Treatment

Guanghao Wu, Zhenya Liu, Changwen Mu, Da Song, Jiaxin Wang, Xiangxi Meng, Ziyuan Li, Hong Qing, Yuping Dong, Hai-Yan Xie, Dai-Wen Pang

ACS Nano· Volume 17· Issue 8
Publisher page

Abstract

The intrinsic features and functions of platelets and mesenchymal stem cells (MSCs) indicate their great potential in the treatment of intracerebral hemorrhage (ICH). However, neither of them can completely overcome ICH because of the stealth process and the complex pathology of ICH. Here, we fabricate hybrid cells for versatile and highly efficient ICH therapy by fusing MSCs with platelets and loading with lysophosphatidic acid-modified PbS quantum dots (LPA-QDs). The obtained LPA-QDs@FCs (FCs = fusion cells) not only inherit the capabilities of both platelets and MSCs but also exhibit clearly enhanced proliferation activated by LPA. After systemic administration, many proliferating LPA-QDs@FCs rapidly accumulate in ICH areas for responding to the vascular damage and inflammation and then efficiently prevent both the primary and secondary injuries of ICH but with no obvious side effects. Moreover, the treatment process can be tracked by near-infrared II fluorescence imaging with highly spatiotemporal resolution, providing a promising solution for ICH therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Intracerebral and Subarachnoid Hemorrhage Research · Autophagy in Disease and Therapy · Kruppel-like factors research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Life Science, Beijing Institute of Technology, Beijing 100081, P. R. China

School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Frontiers Science Center for New Organic Matter, Research Center for Analytical Sciences, College of Chemistry, Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, P. R. China

Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100083, P. R. China

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Peking University, Beijing 100142, P. R. China

Department of Biomedical Engineering, Peking University, Beijing 100871, P. R. China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Haihe Laboratory of Sustainable Chemical Transformations

References (66)

Show source-provided references
1. 10.1038/nrneurol.2010.14610.1038/nrneurol.2010.146 ↗
2. 10.1161/01.STR.0000247868.97078.1010.1161/01.STR.0000247868.97078.10 ↗
3. 10.1016/S1474-4422(12)70104-710.1016/S1474-4422(12)70104-7 ↗
4. 10.1016/S0140-6736(18)31033-X10.1016/S0140-6736(18)31033-X ↗
5. 10.1056/NEJMoa070753410.1056/NEJMoa0707534 ↗
6. 10.1038/nrneurol.2014.26410.1038/nrneurol.2014.264 ↗
7. 10.1073/pnas.201849711710.1073/pnas.2018497117 ↗
8. 10.1126/scitranslmed.aaa685310.1126/scitranslmed.aaa6853 ↗
9. 10.1126/science.121515710.1126/science.1215157 ↗
10. 10.1016/j.stem.2016.08.02010.1016/j.stem.2016.08.020 ↗
11. 10.1016/j.stem.2017.07.00410.1016/j.stem.2017.07.004 ↗
12. 10.1038/s41536-019-0073-810.1038/s41536-019-0073-8 ↗
13. 10.3389/fimmu.2021.79674410.3389/fimmu.2021.796744 ↗
14. 10.1038/s41590-020-0741-210.1038/s41590-020-0741-2 ↗
15. 10.1038/s41581-018-0023-510.1038/s41581-018-0023-5 ↗
16. 10.1038/nrrheum.2017.18210.1038/nrrheum.2017.182 ↗
17. 10.1126/scitranslmed.aba456410.1126/scitranslmed.aba4564 ↗
18. 10.1126/sciadv.aba688410.1126/sciadv.aba6884 ↗
19. 10.1126/sciadv.abb569610.1126/sciadv.abb5696 ↗
20. 10.1021/nl301658q10.1021/nl301658q ↗
21. 10.1021/acsnano.1c0996010.1021/acsnano.1c09960 ↗
22. 10.1021/nn406272610.1021/nn4062726 ↗
23. 10.1126/sciadv.abj053410.1126/sciadv.abj0534 ↗
24. 10.3389/fnins.2019.0046210.3389/fnins.2019.00462 ↗
25. 10.1016/j.ymthe.2020.01.02010.1016/j.ymthe.2020.01.020 ↗
26. 10.3390/molecules2520472310.3390/molecules25204723 ↗
27. 10.1002/cmdc.20060018110.1002/cmdc.200600181 ↗
28. 10.1021/acsnano.8b0490610.1021/acsnano.8b04906 ↗
29. 10.1021/acsnano.9b0169610.1021/acsnano.9b01696 ↗
30. 10.1021/nn501865410.1021/nn5018654 ↗
31. 10.1021/jacs.1c0666110.1021/jacs.1c06661 ↗
32. 10.1016/j.scib.2021.12.00410.1016/j.scib.2021.12.004 ↗
33. 10.1073/pnas.180615311510.1073/pnas.1806153115 ↗
34. 10.3390/jcm1004056610.3390/jcm10040566 ↗
35. 10.15283/ijsc2003510.15283/ijsc20035 ↗
36. 10.1194/jlr.R04645810.1194/jlr.R046458 ↗
37. 10.1016/0092-8674(89)90868-410.1016/0092-8674(89)90868-4 ↗
38. 10.1038/nrc114310.1038/nrc1143 ↗
39. 10.1126/science.121590410.1126/science.1215904 ↗
40. 10.1038/ncomms222110.1038/ncomms2221 ↗
41. 10.1126/scisignal.aaw392110.1126/scisignal.aaw3921 ↗
42. 10.1038/nri295610.1038/nri2956 ↗
43. 10.1038/s41569-018-0110-010.1038/s41569-018-0110-0 ↗
44. 10.1038/s41392-022-01134-410.1038/s41392-022-01134-4 ↗
45. 10.1016/j.stem.2009.02.00110.1016/j.stem.2009.02.001 ↗
46. 10.1124/pr.117.01453010.1124/pr.117.014530 ↗
47. 10.1126/scitranslmed.abb897510.1126/scitranslmed.abb8975 ↗
48. 10.1038/ni.300210.1038/ni.3002 ↗
49. 10.1016/j.stem.2013.09.00610.1016/j.stem.2013.09.006 ↗
50. 10.1016/j.molmed.2018.12.00610.1016/j.molmed.2018.12.006 ↗
51. 10.1097/TA.000000000000148510.1097/TA.0000000000001485 ↗
52. 10.1016/j.jconrel.2020.08.03010.1016/j.jconrel.2020.08.030 ↗
53. 10.1039/C9SC02466B10.1039/C9SC02466B ↗
54. 10.1038/s41551-022-00862-w10.1038/s41551-022-00862-w ↗
55. 10.1038/s41467-021-21047-010.1038/s41467-021-21047-0 ↗
56. 10.1126/scitranslmed.aaf529410.1126/scitranslmed.aaf5294 ↗
57. 10.1126/scitranslmed.aaf433110.1126/scitranslmed.aaf4331 ↗
58. 10.1038/s41551-017-0182-x10.1038/s41551-017-0182-x ↗
59. 10.1016/j.biomaterials.2015.03.02410.1016/j.biomaterials.2015.03.024 ↗
60. 10.1002/anie.20201039110.1002/anie.202010391 ↗
61. 10.1016/j.biomaterials.2021.12116110.1016/j.biomaterials.2021.121161 ↗
62. 10.1126/sciadv.aba058810.1126/sciadv.aba0588 ↗
63. 10.1039/C8BM01480A10.1039/C8BM01480A ↗
64. 10.1016/j.nano.2017.04.00110.1016/j.nano.2017.04.001 ↗
65. 10.1097/00004647-200405000-0000210.1097/00004647-200405000-00002 ↗
66. 10.1161/CIRCULATIONAHA.117.02729010.1161/CIRCULATIONAHA.117.027290 ↗