DataVXACS NanoPaper
journal article·2023-04-25

Chemoimmunological Cascade Cancer Therapy Using Fluorine Assembly Nanomedicine

Qingyan Zhang, Pengkai Wu, Jicheng Wu, Hao Shou, Xinliang Ming, Shuqi Wang, Ben Wang

ACS Nano· Volume 17· Issue 8
Publisher page
Source abstract

Abstract

Classical chemotherapeutic drugs may cause immunogenic cell death (ICD), followed by activating CD8 + T cells to promote cell-mediated antitumor immune responses. However, CD8 + T cells become exhausted due to tumor antigens’ continuous stimulation, creating a major obstacle to effectively suppressing tumor growth and metastasis. Here, we develop an approach of chemo-gene combinational nanomedicine to bridge and reprogram chemotherapy and immunotherapy. The dually loaded nanomedicine induces ICD in tumor cells through doxorubicin and reverses the antitumor effects of exhausted CD8 + T cells through the small interfering RNA. The synergistic chemo-gene and fluorine assembly nanomedicine enriched in reactive oxygen species and acid-sensitive bonds results in enhanced cancer immunotherapy to inhibit tumor growth and the lung metastasis of breast cancer in a mouse model of breast cancer and melanoma. This study provides an efficient strategy and insights into chemoimmunological cascade therapy for combating malignant metastatic tumors.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immunotherapy and Immune Responses · Cancer Immunotherapy and Biomarkers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China

Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China

Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

Department of Respiratory and Critical Care Medicine, Provincial Clinical Research Center for Respiratory Diseases, West China Hospital, Sichuan University, Chengdu 610041, China

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China

Cancer Center, Zhejiang University, Hangzhou 310029, China

Funding

Ministry of Science and Technology of the People's Republic of China · Central University Basic Research Fund of China · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province

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