journal article·2020-04-28Open access

Biomimetic Presentation of Cryptic Ligands via Single-Chain Nanogels for Synergistic Regulation of Stem Cells

Xiaoyu Chen, Nathanael Chun-Him Lai, Kongchang Wei, Rui Li, Miao Cui, Boguang Yang, Siu Hong Dexter Wong, Yingrui Deng, Jiashen Li, Xintao Shuai, Liming Bian

ACS Nano· Volume 14· Issue 4

Abstract

Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such a carefully designed SCNG is capable of mediating a triggered copresentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. This controllable nanoswitching-on of cell-adhesive ligands' presentation allows the regulation of cell adhesion and fate from molecular scale. The modular nature of this synthetic macromolecular nanoregulator makes it a versatile nanomaterial platform to assist basic and fundamental studies in a wide array of research topics.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cellular Mechanics and Interactions · 3D Printing in Biomedical Research · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR 999077, P.R. China

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR 999077, P.R. China

Department of Materials, The University of Manchester, Manchester M13 9PL, United Kingdom

PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China

Shenzhen Research Institute, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong 999077, P.R. China

Centre for Novel Biomaterials, The Chinese University of Hong Kong, Hong Kong SAR 999077, P.R. China

Funding

Health and Medical Research Fund · Research Grants Council, University Grants Committee · Chinese University of Hong Kong · Hong Kong University of Science and Technology · Chow Yuk Ho Technology Centre for Innovative Medicine, Chinese University of Hong Kong

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