Flipped Quick-Response Code Enables Reliable Blood Grouping

Hong Zhang; Ruining Liu; Qingmei Li; Xiaolin Hu; Lixiang Wu; Ye Zhou; Guangchao Qing; Rui Yuan; Junjie Huang; Wei Gu; Yanyao Ye; Chao Qi; Mei Han; Xiaohui Chen; Xun Zhu; Yun Deng; Liangliang Zhang; Hengyi Chen; Haoran Zhang; Weiyin Gao; Yao Liu; Yang Luo

doi:10.1021/acsnano.1c01215

journal article·2021-04-27

Flipped Quick-Response Code Enables Reliable Blood Grouping

Hong Zhang, Ruining Liu, Qingmei Li, Xiaolin Hu, Lixiang Wu, Ye Zhou, Guangchao Qing, Rui Yuan, Junjie Huang, Wei Gu, Yanyao Ye, Chao Qi, Mei Han, Xiaohui Chen, Xun Zhu, Yun Deng, Liangliang Zhang, Hengyi Chen, Haoran Zhang, Weiyin Gao, Yao Liu, Yang Luo

ACS Nano· Volume 15· Issue 4

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Source abstract

Abstract

Accurate and rapid blood typing plays a vital role in a variety of biomedical and forensic scenarios, but recognizing weak agglutination remains challenging. Herein, we demonstrated a flipping identification with a prompt error-discrimination (FLIPPED) platform for automatic blood group readouts. Bromocresol green dye was exploited as a characteristic chromatography indicator for the differentiation of plasma from whole blood by presenting a teal color against a brown color. After integrating these color changes into a quick-response (QR) code, prompt typing of ABO and Rhesus groups was automatically achieved and data could be uploaded wirelessly within 30 s using a commercially available smartphone to facilitate blood cross-matching. We further designed a color correction model and algorithm to remove potential errors from scanning angles and ambient light intensities, by which weak agglutination could be accurately recognized. With comparable accuracy and repeatability to classical column assay in grouping 450 blood samples, the proposed approach further demonstrates to be a versatile sample-to-result platform for clinical diagnostics, food safety, and environmental monitoring.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Biosensors and Analytical Detection · Microfluidic and Capillary Electrophoresis Applications · SARS-CoV-2 detection and testing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, People’s Republic of China

College of Bioengineering, Chongqing University, Chongqing 400044, People’s Republic of China

Chongqing University Cancer Hospital, Chongqing 400044, People’s Republic of China

College of Biomedical Engineering, Chongqing Medical University, Chongqing 400042, People’s Republic of China

Department of Laboratory Medicine, Chongqing High-tech Zone People’s Hospital, Chongqing 400039, People’s Republic of China

Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, People’s Republic of China

Chongqing Public Health Medical Center, Chongqing 400030, People’s Republic of China

School of Energy and Power Engineering, Institute of Engineering Thermophysics, Chongqing University, Chongqing 400044, People’s Republic of China

Department of Emergency, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China

Funding

Chongqing Municipal Education Commission · Ministry of Education of the People's Republic of China · Natural Science Foundation of Chongqing · National Natural Science Foundation of China · Open Foundation of Key Laboratory of Wuliangye-flavor Liquor Solid-state Fermentation, China National Light Industry

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