journal article·2018-08-28

Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

Connor Howe, Saswat Mishra, Yun-Soung Kim, Yanfei Chen, Sang-Ho Ye, William R. Wagner, Jae-Woong Jeong, Hun-Soo Byun, Jong-Hoon Kim, Youngjae Chun, Woon-Hong Yeo

ACS Nano· Volume 12· Issue 8
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Abstract

Random weakening of an intracranial blood vessel results in abnormal blood flow into an aneurysmal sac. Recent advancements show that an implantable flow diverter, integrated with a medical stent, enables a highly effective treatment of cerebral aneurysms by guiding blood flow into the normal vessel path. None of such treatment systems, however, offers post-treatment monitoring to assess the progress of sac occlusion. Therefore, physicians rely heavily on either angiography or magnetic resonance imaging. Both methods require a dedicated facility with sophisticated equipment settings and time-consuming, cumbersome procedures. In this paper, we introduce an implantable, stretchable, nanostructured flow-sensor system for quantification of intra-aneurysmal hemodynamics. The open-mesh membrane device is capable of effective implantation in complex neurovascular vessels with extreme stretchability (500% radial stretching) and bendability (180° with 0.75 mm radius of curvature) for monitoring of the treatment progress. A collection of quantitative mechanics, fluid dynamics, and experimental studies establish the fundamental aspects of design criteria for a highly compliant, implantable device. Hemocompatibility study using fresh ovine blood captures the device feasibility for long-term insertion in a blood vessel, showing less platelet deposition compared to that in existing implantable materials. In vitro demonstrations of three types of flow sensors show quantification of intra-aneurysmal blood flow in a pig aorta and the capability of observation of aneurysm treatment with a great sensitivity (detection limit as small as 0.032 m/s). Overall, this work describes a mechanically soft flow-diverter system that offers an effective treatment of aneurysms with an active monitoring of intra-aneurysmal hemodynamics.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Intracranial Aneurysms: Treatment and Complications · Micro and Nano Robotics · Vascular Malformations Diagnosis and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Mechanical and Nuclear Engineering, Institute for Engineering and Medicine, Center for Rehabilitation Science and Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, United States

George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea 34141

Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu, Jeonnam 59626, South Korea

School of Engineering and Computer Science, Washington State University, Vancouver, Washington 98686, United States

Institute for Electronics and Nanotechnology, Bioengineering Interdisciplinary Program, Petit Institute for Bioengineering & Bioscience, and Center for Flexible Electronics, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

Funding

Korea Research Council for Industrial Science and Technology · Georgia Tech Institute for Electronics and Nanotechnology, a member of the National Nanotechnology Coordinated Infrastructure, supported by the National Science Foundation · Woodruff School of Mechanical Engineering, Georgia Institute of Technology · Central Research Development Fund, University of Pittsburgh · Institute for Electronics and Nanotechnology, Georgia Institute of Technology

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