DataVXACS NanoPaper
journal article·2021-11-23

Tumor Microenvironment Responsive “Head-to-Foot” Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects

Ling Qiu, Ke Li, Wenyi Dong, Yann Seimbille, Qingzhu Liu, Feng Gao, Jianguo Lin

ACS Nano· Volume 15· Issue 11
Publisher page
Source abstract

Abstract

Sensitivity and specificity of molecular probes are two important factors in determining the accuracy of cancer diagnosis or the efficacy of cancer treatment. However, the development of probes with high sensitivity and strong specificity still poses many challenges. Herein, we report an 18F-labeled smart tracer ([18F]1) targeting cancer-associated biotin receptor (BR) and self-assembling into nanoparticles in response to intracellular glutathione. The tracer [18F]1 selectively targeted BR-positive cancer cells A549 and Hela and formed nanoparticles through self-assembly with an average diameter of 138.2 ± 16.3 nm. The character of self-assembly into nanoparticles enhanced the uptake and extended the retention of probe [18F]1 in the target tissue and hence improved the quality of positron emission tomography (PET) images. Thus, [18F]1 is a promising PET tracer for accurately detecting BR-positive cancers. Moreover, the tumor microenvironment responsive “head-to-foot” self-assembly nanoplatform is particularly attractive for development of other smart molecular probes.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Click Chemistry and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China

Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China

Department of Radiology and Nuclear Medicine, University Medical Center Rotterdam, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands

Laboratory for Experimental Teratology of the Ministry of Education and Biomedical Isotope Research Center, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Innovation Capacity Development Plan of Jiangsu Province · Major Scientific Research Project of Jiangsu Commission of Health · Major Scientific Research Project of Wuxi Commission of Health

References (56)

Show source-provided references
1. 10.3322/caac.2149210.3322/caac.21492 ↗
2. 10.3322/caac.2159010.3322/caac.21590 ↗
3. 10.1016/j.crad.2010.03.01110.1016/j.crad.2010.03.011 ↗
4. 10.1016/j.addr.2013.09.00710.1016/j.addr.2013.09.007 ↗
5. 10.1021/cr078242610.1021/cr0782426 ↗
6. 10.1038/nrclinonc.2015.7510.1038/nrclinonc.2015.75 ↗
7. 10.1038/bjc.2014.61010.1038/bjc.2014.610 ↗
8. 10.1016/j.nec.2020.08.00310.1016/j.nec.2020.08.003 ↗
9. 10.2174/156802661566615030211032510.2174/1568026615666150302110325 ↗
10. 10.1016/j.addr.2016.08.00110.1016/j.addr.2016.08.001 ↗
11. 10.1039/c3cs60048c10.1039/c3cs60048c ↗
12. 10.1038/s41585-019-0272-510.1038/s41585-019-0272-5 ↗
13. 10.1016/j.jinorgbio.2004.07.00910.1016/j.jinorgbio.2004.07.009 ↗
14. 10.1016/j.drudis.2009.12.00310.1016/j.drudis.2009.12.003 ↗
15. 10.1002/med.2138710.1002/med.21387 ↗
16. 10.1007/978-94-007-2199-9_110.1007/978-94-007-2199-9_1 ↗
17. 10.1038/ncomms872610.1038/ncomms8726 ↗
18. 10.1002/anie.20131113310.1002/anie.201311133 ↗
19. 10.1039/C5CC03075G10.1039/C5CC03075G ↗
20. 10.1016/j.ejmech.2018.01.00110.1016/j.ejmech.2018.01.001 ↗
21. 10.1016/j.jphotobiol.2018.09.00110.1016/j.jphotobiol.2018.09.001 ↗
22. 10.1039/D0SC01973A10.1039/D0SC01973A ↗
23. 10.1038/s41467-020-16118-710.1038/s41467-020-16118-7 ↗
24. 10.1016/S0891-5849(99)00177-X10.1016/S0891-5849(99)00177-X ↗
25. 10.1038/s41416-020-01156-110.1038/s41416-020-01156-1 ↗
26. 10.1021/acs.accounts.5b0000910.1021/acs.accounts.5b00009 ↗
27. 10.1002/anie.20200914110.1002/anie.202009141 ↗
28. 10.1021/ja401350x10.1021/ja401350x ↗
29. 10.7150/thno.3274210.7150/thno.32742 ↗
30. 10.1002/anie.20161264710.1002/anie.201612647 ↗
31. 10.1039/C9TB01597C10.1039/C9TB01597C ↗
32. 10.2967/jnumed.116.18805210.2967/jnumed.116.188052 ↗
33. 10.1007/s00259-019-04543-w10.1007/s00259-019-04543-w ↗
34. 10.1038/nchem.48010.1038/nchem.480 ↗
35. 10.1038/nchem.192010.1038/nchem.1920 ↗
36. 10.1002/anie.20191331410.1002/anie.201913314 ↗
37. 10.1021/acs.analchem.0c0125310.1021/acs.analchem.0c01253 ↗
38. 10.1021/jacs.0c0759410.1021/jacs.0c07594 ↗
39. 10.1021/acs.analchem.8b0270410.1021/acs.analchem.8b02704 ↗
40. 10.1021/acs.nanolett.8b0515410.1021/acs.nanolett.8b05154 ↗
41. 10.1021/acs.analchem.9b0478810.1021/acs.analchem.9b04788 ↗
42. 10.1021/acs.analchem.1c0074710.1021/acs.analchem.1c00747 ↗
43. 10.1039/C6NR09895A10.1039/C6NR09895A ↗
44. 10.1021/acsnano.9b1014410.1021/acsnano.9b10144 ↗
45. 10.1021/ja802734t10.1021/ja802734t ↗
46. 10.1016/j.apradiso.2011.05.00510.1016/j.apradiso.2011.05.005 ↗
47. 10.1021/acs.jmedchem.0c0049410.1021/acs.jmedchem.0c00494 ↗
48. 10.1016/j.nucmedbio.2012.08.00110.1016/j.nucmedbio.2012.08.001 ↗
49. 10.1039/D0SM00670J10.1039/D0SM00670J ↗
50. 10.1002/anie.20200572910.1002/anie.202005729 ↗
51. 10.1038/nprot.2015.09010.1038/nprot.2015.090 ↗
52. 10.1016/S0928-0987(97)10019-710.1016/S0928-0987(97)10019-7 ↗
53. 10.1211/002235704487810.1211/0022357044878 ↗
54. 10.1021/acs.jmedchem.0c0089310.1021/acs.jmedchem.0c00893 ↗
55. 10.1039/c3cc42653j10.1039/c3cc42653j ↗
56. 10.1021/ja401007810.1021/ja4010078 ↗