DataVXACS NanoPaper
journal article·2021-10-26Open access

Plasmonic-Assisted Thermocyclizations in Living Cells Using Metal–Organic Framework Based Nanoreactors

Carolina Carrillo-Carrión, Raquel Martínez, Ester Polo, María Tomás-Gamasa, Paolo Destito, Manuel Ceballos, Beatriz Pelaz, Fernando López, José L. Mascareñas, Pablo del Pino

ACS Nano· Volume 15· Issue 10
Publisher pageOpen full text
Source abstract

Abstract

We describe a microporous plasmonic nanoreactor to carry out designed near-infrared (NIR)-driven photothermal cyclizations inside living cells. As a proof of concept, we chose an intramolecular cyclization that is based on the nucleophilic attack of a pyridine onto an electrophilic carbon, a process that requires high activation energies and is typically achieved in bulk solution by heating at ∼90 °C. The core-shell nanoreactor (NR) has been designed to include a gold nanostar core, which is embedded within a metal-organic framework (MOF) based on a polymer-stabilized zeolitic imidazole framework-8 (ZIF-8). Once accumulated inside living cells, the MOF-based cloak of NRs allows an efficient diffusion of reactants into the plasmonic chamber, where they undergo the transformation upon near-IR illumination. The photothermal-driven reaction enables the intracellular generation of cyclic fluorescent products that can be tracked using fluorescence microscopy. The strategy may find different type of applications, such as for the spatio-temporal activation of prodrugs.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Click Chemistry and Applications · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Física de Partículas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Inorgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Misión Biológica de Galicia, Consejo Superior de Investigaciones Científicas (CSIC), 36080 Pontevedra, Spain

Funding

European Commission · Ministerio de Econom??a, Industria y Competitividad, Gobierno de Espa??a · Ministerio de Ciencia e Innovaci??n · H2020 Marie Sk??odowska-Curie Actions · H2020 Future and Emerging Technologies · Xunta de Galicia · FP7 Ideas: European Research Council · H2020 European Research Council

References (44)

Show source-provided references
1. 10.1002/anie.20170840810.1002/anie.201708408 ↗
2. 10.1016/j.ccr.2018.01.01110.1016/j.ccr.2018.01.011 ↗
3. 10.1039/b901970g10.1039/b901970g ↗
4. 10.1021/ar200037t10.1021/ar200037t ↗
5. 10.1021/ar200021p10.1021/ar200021p ↗
6. 10.1039/C8CS00395E10.1039/C8CS00395E ↗
7. 10.1039/C4CS00117F10.1039/C4CS00117F ↗
8. 10.1021/jacs.9b0083710.1021/jacs.9b00837 ↗
9. 10.1038/s41467-018-04314-510.1038/s41467-018-04314-5 ↗
10. 10.1002/anie.20200203210.1002/anie.202002032 ↗
11. 10.1002/chem.20200392710.1002/chem.202003927 ↗
12. 10.1038/nchem.229110.1038/nchem.2291 ↗
13. 10.1002/adhm.20200162710.1002/adhm.202001627 ↗
14. 10.1016/j.cbpa.2020.10.00110.1016/j.cbpa.2020.10.001 ↗
15. 10.1002/anie.20210889910.1002/anie.202108899 ↗
16. 10.1021/acscentsci.8b0025110.1021/acscentsci.8b00251 ↗
17. 10.1039/C3MH00106G10.1039/C3MH00106G ↗
18. 10.1016/j.nantod.2018.04.00310.1016/j.nantod.2018.04.003 ↗
19. 10.1039/C5NH00073D10.1039/C5NH00073D ↗
20. 10.2217/nnm.15.10310.2217/nnm.15.103 ↗
21. 10.2217/nnm.14.15510.2217/nnm.14.155 ↗
22. 10.1016/j.apmt.2019.04.01310.1016/j.apmt.2019.04.013 ↗
23. 10.1002/anie.20190281710.1002/anie.201902817 ↗
24. 10.1021/nn505468v10.1021/nn505468v ↗
25. 10.1021/acsnano.9b0875210.1021/acsnano.9b08752 ↗
26. 10.1126/science.aat696710.1126/science.aat6967 ↗
27. 10.1038/nmat345410.1038/nmat3454 ↗
28. 10.1038/ncomms1454210.1038/ncomms14542 ↗
29. 10.1021/acs.chemrev.7b0043010.1021/acs.chemrev.7b00430 ↗
30. 10.1021/acs.nanolett.0c0218010.1021/acs.nanolett.0c02180 ↗
31. 10.1126/science.aan847810.1126/science.aan8478 ↗
32. 10.1021/acsnano.5b0662310.1021/acsnano.5b06623 ↗
33. 10.1021/acscatal.8b0400510.1021/acscatal.8b04005 ↗
34. 10.1038/ncomms427710.1038/ncomms4277 ↗
35. 10.1002/anie.20170560910.1002/anie.201705609 ↗
36. 10.1016/j.xcrp.2020.10007610.1016/j.xcrp.2020.100076 ↗
37. 10.1021/ja405187310.1021/ja4051873 ↗
38. 10.1021/acs.accounts.8b0052110.1021/acs.accounts.8b00521 ↗
39. 10.1016/j.nantod.2018.02.01010.1016/j.nantod.2018.02.010 ↗
40. 10.1016/S0009-2614(03)00506-210.1016/S0009-2614(03)00506-2 ↗
41. 10.1021/acsami.7b0666210.1021/acsami.7b06662 ↗
42. 10.1021/nn300223w10.1021/nn300223w ↗
43. 10.1021/acs.orglett.6b0147510.1021/acs.orglett.6b01475 ↗
44. 10.1021/la802448z10.1021/la802448z ↗