DataVXACS NanoPaper
journal article·2021-08-24

A Monotargeting Peptidic Network Antibody Inhibits More Receptors for Anti-Angiogenesis

Kuo Zhang, Hui Zhang, Yong-Hong Gao, Jia-Qi Wang, Yuan Li, Hui Cao, Ying Hu, Lei Wang

ACS Nano· Volume 15· Issue 8
Publisher page
Source abstract

Abstract

The overexpression of growth factors and receptors on neovascular endothelial cells (ECs) and their binding may promote the abnormal growth of new blood vessels, leading to corneal neovascularization (CNV). Normally, monoclonal antibodies may bind and block only one growth factor or receptor, such as bevacizumab binding and blocking vascular endothelial growth factor (VEGF). Herein, we develop a monotargeting peptidic network antibody (pepnetibody) that blocks multiple receptors on the membrane of ECs through forming a fibrous network and ultimately achieves high-efficient treatment of CNV. The pepnetibody could bind to integrin αvβ3 in particulate formulation and in situ fibrillogenesis on ECs, mimicking the process of fibronectin fibrillogenesis on the cell membrane. The in situ formed peptidic network could firmly block integrin and cover other angiogenesis-related receptors, such as VEGF receptor-2 and neuropilin-1, exhibiting competitive efficacy of antiangiogenesis compared with traditional monoclonal antibody bevacizumab with 97.7 times lower dose.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Corneal Surgery and Treatments · Protease and Inhibitor Mechanisms · Proteoglycans and glycosaminoglycans research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Physics and Chemistry, School of Materials Science and Engineering, University of Science and Technology Beijing, No. 30 Xueyuan Road, Beijing, 100083, China

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China

Shanghai Jiao Tong University School of Medicine, 227 Chongqing South Road, Shanghai, 200025, China

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600, Yishan Road, Shanghai, 200233, China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

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