journal article·2022-05-24

Shape Designed Implanted Drug Delivery System for In Situ Hepatocellular Carcinoma Therapy

Chaochao Zhao, Qin Shi, Hu Li, Xi Cui, Yuan Xi, Yu Cao, Zhuo Xiang, Feng Li, Jinyan Sun, Jiacheng Liu, Tongqiang Li, Wei Wei, Bin Xiong, Zhou Li

ACS Nano· Volume 16· Issue 5
Publisher page

Abstract

In this study, an intelligent drug delivery system (DDS) based on implanted triboelectric nanogenerator (iTENG) and red blood cell (RBC) is established for in situ hepatocellular carcinoma (HCC) therapy. Apatinib (APA), as an oral antitumor drug, which can inhibit the expression of vascular endothelial growth factor receptor-2 (VEGFR2) is loaded inside RBC, realizing the transform from oral formulation to injection preparation. Multishape designed iTENG adapted for different implant sites and environments can harvest biomechanical energy efficiently. The electric field (EF) generated by the iTENG can increase the release of APA, and the release will decrease quickly when the EF disappears, which shows that the DDS is highly controllable. The controllable DDS demonstrates an exciting killing ability of HCC cells both in vitro and in vivo with strikingly reduced APA dosage. After implantation, the self-powered DDS has a prominent therapeutic effect of HCC-bearing rabbits, which is expected to be applied in clinical medicine.
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Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, China

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Funding

Guangdong Science and Technology Department · Natural Science Foundation of Beijing Municipality · Foshan University · National Natural Science Foundation of China · Foshan Bureau of Finance

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