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journal article·2021-10-26Open access

Dipeptide Nanostructure Assembly and Dynamics via in Situ Liquid-Phase Electron Microscopy

Karthikeyan Gnanasekaran, Joanna Korpanty, Or Berger, Nicholas Hampu, Michal Halperin-Sternfeld, Dana Cohen-Gerassi, Lihi Adler-Abramovich, Nathan C. Gianneschi

ACS Nano· Volume 15· Issue 10
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Source abstract

Abstract

In this paper, we report the in situ growth of FF nanotubes examined via liquid-cell transmission electron microscopy (LCTEM). This direct, high spatial, and temporal resolution imaging approach allowed us to observe the growth of peptide-based nanofibrillar structures through directional elongation. Furthermore, the radial growth profile of FF nanotubes through the addition of monomers perpendicular to the tube axis has been observed in real-time with sufficient resolution to directly observe the increase in diameter. Our study demonstrates that the kinetics, dynamics, structure formation, and assembly mechanism of these supramolecular assemblies can be directly monitored using LCTEM. The performance of the peptides and the assemblies they form can be verified and evaluated using post-mortem techniques including time-of-flight secondary ion mass spectrometry (ToF-SIMS).
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Research context

Nanomaterials

OpenAlex topics: Advanced Electron Microscopy Techniques and Applications · Supramolecular Self-Assembly in Materials · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States

Department of Materials Science & Engineering, Department of Biomedical Engineering, Department of Pharmacology, Northwestern University, Evanston, Illinois 60208, United States

Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel

Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel

Funding

Israel Science Foundation · Army Research Office · Human Frontier Science Program · National Institutes of Health · National Science Foundation · Division of Materials Research · Argonne National Laboratory · Clore Scholarship

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