DataVXACS NanoPaper
journal article·2022-04-26

Targeted Intervention of NF2–YAP Signaling Axis in CD24-Overexpressing Cells Contributes to Encouraging Therapeutic Effects in TNBC

Lingmi Hou, Lulan Pu, Yu Chen, Yuting Bai, Yuqing Zhou, Maoshan Chen, Shuqi Wang, Yipin Lv, Cui Ma, Panke Cheng, Kaijiong Zhang, Qi Liang, Shishan Deng, Dongsheng Wang

ACS Nano· Volume 16· Issue 4
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Source abstract

Abstract

Triple-negative breast cancer (TNBC) cells have not been usefully classified, and no targeted therapeutic plans are currently available, resulting in a high recurrence rate and metastasis potential. In this research, CD24high cells accounted for the vast majority of TNBC cells, and they were insensitive to Taxol but sensitive to ferroptosis agonists and effectively escaped phagocytosis by tumor-associated macrophages. Furthermore, the NF2–YAP signaling axis modulated the expression of ferroptosis suppressor protein 1 (FSP1) and CD24 in CD24high cells, with subsequent ferroptotic regulation and macrophage phagocytosis. In addition, a precision targeted therapy system was designed based on the pH level and glutathione response, and it can be effectively used to target CD24high cells to induce lysosomal escape and drug burst release through CO2 production, resulting in enhanced ferroptosis and macrophage phagocytosis through FSP1 and CD24 inhibition mediated by the NF2–YAP signaling axis. This system achieved dual antitumor effects, ultimately promoting cell death and thus inhibiting TNBC tumor growth, with some tumors even disappearing. The composite nanoprecision treatment system reported in this paper is a potential strategic tool for future use in the treatment of TNBC.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsComposites

OpenAlex topics: Ferroptosis and cancer prognosis · Cancer Cells and Metastasis · Cancer Immunotherapy and Biomarkers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Academician (expert) Workstation, Biological Targeting Laboratory of Breast Cancer, Breast and Thyroid Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, People’s Republic of China

Department of Breast and Thyroid Surgery, Yingshan Hospital of West China Hospital, Sichuan University, Nanchong, Sichuan 673000, People’s Republic of China

Department of Anatomy, North Sichuan Medical College, Nanchong, Sichuan 637000, People’s Republic of China

Department of Laboratory Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, People’s Republic of China

Department of Breast and Thyroid Surgery, Affiliated Suining Central Hospital of Chongqing Medical University, Suining, Sichuan 629000, People’s Republic of China

Department of Digestive Diseases, The General Hospital of Western Theater Command, Chengdu, Sichuan 610036, People’s Republic of China

Department of Mathematics, Army Medical University, Chongqing 400038, People’s Republic of China

Department of Cardiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, People’s Republic of China

Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu, Sichuan 610041, People’s Republic of China

Funding

National Natural Science Foundation of China · Foundation of the TCM Basic Project of Sichuan TCM Administration · Foundation of Nanchong Municipal University Cooperative Research · Nanchong Municipal Science and Technology Bureau · Nanchong city · Foundation of the Sichuan TCM Administration · Foundation of the Project of Chengdu Science and Technology

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