DataVXACS NanoPaper
journal article·2021-01-26

Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Pharmacokinetics of Smart Nanomaterials

Lu Zhang, Yi Wu, Xingbin Yin, Zheng Zhu, Tatu Rojalin, Wenwu Xiao, Dalin Zhang, Yanyu Huang, Longmeng Li, Christopher M. Baehr, Xingjian Yu, Yousif Ajena, Yuanpei Li, Lei Wang, Kit S. Lam

ACS Nano· Volume 15· Issue 1
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Source abstract

Abstract

To be clinically efficacious, nanotherapeutic drugs need to reach disease tissues reliably and cause limited side effects to normal organs and tissues. Here, we report a proof-of-concept study on the development of a smart peptidic nanophototherapeutic agent in line with clinical requirements, which can transform its morphology from nanoparticles to nanofibrils at the tumor sites. This in vivo receptor-mediated transformation process resulted in the formation and prolonged tumor-retention of highly ordered (J-aggregate type of photosensitizer) photosensitive peptide nanofibrillar network with greatly enhanced photothermal and photodynamic properties. This strategy of “multiple daily low-intensity laser radiation after each intravenous injection of significantly low-dose of nanomaterials” demonstrated effective elimination of 4T1 orthotopic syngeneic breast cancer in mice. The technology for nanomaterial modulation based on living cell surface receptors, in this case tumor-associated α3β1 integrin, has great potential for clinical translation and is expected to improve the therapeutic efficacy against many cancers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Antimicrobial Peptides and Activities · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry & Molecular Medicine, UC Davis NCI-designated Comprehensive Cancer Center, University of California Davis, Sacramento, California 95817, United States

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China

Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, California 95817, United States

Funding

National Cancer Institute · National Institute of Child Health and Human Development · National Institute of Biomedical Imaging and Bioengineering · National Natural Science Foundation of China

References (38)

Show source-provided references
1. 10.1038/nnano.2015.1710.1038/nnano.2015.17 ↗
2. 10.1002/adma.20190785510.1002/adma.201907855 ↗
3. 10.1021/acs.nanolett.8b0309610.1021/acs.nanolett.8b03096 ↗
4. 10.1038/ncomms571210.1038/ncomms5712 ↗
5. 10.1039/C8CS00001H10.1039/C8CS00001H ↗
6. 10.1002/adma.20160592810.1002/adma.201605928 ↗
7. 10.1021/acsnano.9b0431510.1021/acsnano.9b04315 ↗
8. 10.1002/adfm.20190980610.1002/adfm.201909806 ↗
9. 10.1002/adhm.20190040910.1002/adhm.201900409 ↗
10. 10.1002/anie.20190871210.1002/anie.201908712 ↗
11. 10.1038/ncomms1588010.1038/ncomms15880 ↗
12. 10.1002/adfm.20180687710.1002/adfm.201806877 ↗
13. 10.1021/cr400532z10.1021/cr400532z ↗
14. 10.1021/acsnano.7b0911210.1021/acsnano.7b09112 ↗
15. 10.1021/acs.nanolett.9b0475210.1021/acs.nanolett.9b04752 ↗
16. 10.1021/jacs.7b1158210.1021/jacs.7b11582 ↗
17. 10.1246/bcsj.2018003810.1246/bcsj.20180038 ↗
18. 10.1021/acs.chemrev.8b0019510.1021/acs.chemrev.8b00195 ↗
19. 10.1002/anie.20181455210.1002/anie.201814552 ↗
20. 10.1002/anie.20180699210.1002/anie.201806992 ↗
21. 10.1038/s41565-019-0626-410.1038/s41565-019-0626-4 ↗
22. 10.1186/s13550-016-0165-z10.1186/s13550-016-0165-z ↗
23. 10.1002/adma.20160586910.1002/adma.201605869 ↗
24. 10.1038/nn96810.1038/nn968 ↗
25. 10.1038/nm78310.1038/nm783 ↗
26. 10.1038/nature1072010.1038/nature10720 ↗
27. 10.1021/jacs.8b0808810.1021/jacs.8b08088 ↗
28. 10.1002/ange.20190775410.1002/ange.201907754 ↗
29. 10.1021/jp972337210.1021/jp9723372 ↗
30. 10.1002/ange.20190982510.1002/ange.201909825 ↗
31. 10.1002/anie.20200284310.1002/anie.202002843 ↗
32. 10.1021/jacs.6b0519210.1021/jacs.6b05192 ↗
33. 10.1021/nl201400z10.1021/nl201400z ↗
34. 10.1021/acsnano.6b0872010.1021/acsnano.6b08720 ↗
35. 10.1002/adma.20180210510.1002/adma.201802105 ↗
36. 10.1039/C6NR03656B10.1039/C6NR03656B ↗
37. 10.1021/acsmaterialslett.9b0036910.1021/acsmaterialslett.9b00369 ↗
38. 10.1002/adbi.20160003810.1002/adbi.201600038 ↗