DataVXACS NanoPaper
journal article·2020-12-22

A Soft, Conductive External Stent Inhibits Intimal Hyperplasia in Vein Grafts by Electroporation and Mechanical Restriction

Li Ding, Chen Hang, Shiyu Cheng, Liujun Jia, Lei Mou, Lixue Tang, Chunliang Zhang, Yangzhouyun Xie, Wenfu Zheng, Yan Zhang, Xingyu Jiang

ACS Nano· Volume 14· Issue 12
Publisher page
Source abstract

Abstract

Intimal hyperplasia (IH) in vein grafts (VGs) is a major issue in coronary artery bypass grafting (CABG) surgery. Although external stents can attenuate IH of VGs to some extent, none of the existing external stents have shown satisfactory clinical outcomes. Here we develop a flexible, biodegradable, and conductive external metal-polymer conductor stent (MPCS) that can electroporate the vessel wall and produce a protein that prevents IH. We designed the plasmid DNA encoding the tissue inhibitor of metalloproteinases-3 (TIMP-3) and lyophilized it on the inner surface of the MPCS to deliver into the adventitia and the middle layer of VGs for gene therapy. Coupled with its continuous mechanical support to prevent dilation after implanting, the MPCS can inhibit the IH of VGs significantly in the rabbit model. This proof-of-concept demonstration may aid the development of other implantable bioelectronics for electroporation gene therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Advanced Machining and Optimization Techniques · Electrodeposition and Electroless Coatings

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

Department of Biomedical Engineering and Shenzhen Bay Laboratory, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, China

National Center for NanoScience and Technology and University of Chinese Academy of Sciences, Beijing 100190, China

Funding

Ministry of Science and Technology of the People's Republic of China · Peking Union Medical College · National Natural Science Foundation of China · Chinese Academy of Sciences · Tencent Foundation · Shenzhen Bay Laboratory · Beijing Science and Technology Planning Project

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