DataVXACS NanoPaper
journal article·2019-01-22

End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin-ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

ACS Nano· Volume 13· Issue 1
Publisher page
Source abstract

Abstract

Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science (CEMS), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research (CPR), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan

Research Resources Division, RIKEN Center for Brain Science (CBS), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Funding

Japan Society for the Promotion of Science

References (34)

Show source-provided references
1. 10.1038/nmat244210.1038/nmat2442 ↗
2. 10.1021/cr300441a10.1021/cr300441a ↗
3. 10.1016/j.jmps.2013.08.01810.1016/j.jmps.2013.08.018 ↗
4. 10.1038/nnano.2016.16010.1038/nnano.2016.160 ↗
5. 10.1038/nbt.333010.1038/nbt.3330 ↗
6. 10.1002/adhm.20140064110.1002/adhm.201400641 ↗
7. 10.1038/nnano.2007.7010.1038/nnano.2007.70 ↗
8. 10.1039/C6NR03543D10.1039/C6NR03543D ↗
9. 10.1016/j.nano.2015.11.01310.1016/j.nano.2015.11.013 ↗
10. 10.1016/j.biomaterials.2010.06.05110.1016/j.biomaterials.2010.06.051 ↗
11. 10.1038/srep2456710.1038/srep24567 ↗
12. 10.1073/pnas.121689311010.1073/pnas.1216893110 ↗
13. 10.1021/nn103344k10.1021/nn103344k ↗
14. 10.1016/j.biomaterials.2009.09.06010.1016/j.biomaterials.2009.09.060 ↗
15. 10.1039/C4CC08686D10.1039/C4CC08686D ↗
16. 10.1002/psc.130410.1002/psc.1304 ↗
17. Ueda M. · 2017 · 1 · 19
18. 10.1038/pj.2013.410.1038/pj.2013.4 ↗
19. 10.1021/acs.jpcb.8b0341910.1021/acs.jpcb.8b03419 ↗
20. 10.1021/acsomega.8b0107310.1021/acsomega.8b01073 ↗
21. 10.1039/c2cs35172b10.1039/c2cs35172b ↗
22. 10.1021/nl060468l10.1021/nl060468l ↗
23. 10.1021/jacs.5b0994110.1021/jacs.5b09941 ↗
24. 10.1016/j.actbio.2009.01.00610.1016/j.actbio.2009.01.006 ↗
25. 10.1002/adma.20080270010.1002/adma.200802700 ↗
26. 10.1002/mabi.20080007110.1002/mabi.200800071 ↗
27. 10.1083/jcb.123.5.110710.1083/jcb.123.5.1107 ↗
28. 10.1083/jcb.127.5.121710.1083/jcb.127.5.1217 ↗
29. 10.1083/jcb.20090808610.1083/jcb.200908086 ↗
30. 10.1021/nl403949h10.1021/nl403949h ↗
31. 10.1038/nnano.2011.15110.1038/nnano.2011.151 ↗
32. 10.1016/j.jmps.2013.08.01810.1016/j.jmps.2013.08.018 ↗
33. 10.1038/nature0145110.1038/nature01451 ↗
34. 10.1016/j.jconrel.2016.07.02810.1016/j.jconrel.2016.07.028 ↗