journal article·2020-11-24

Bioactive Core–Shell CaF2 Upconversion Nanostructure for Promotion and Visualization of Engineered Bone Reconstruction

Zhihao Li, Haoran Liu, Rui Wang, Chenhui Ji, Yan Wei, Miusi Shi, Yingqian Wang, Yaping Du, Yufeng Zhang, Quan Yuan, Chunhua Yan

ACS Nano· Volume 14· Issue 11
Publisher page

Abstract

Inorganic ion metabolism plays significant roles in various life processes including signal transduction, substance exchange, and cellular constructions. Regulation and monitoring of ion metabolism offer great promise to modulate biological activities and provide insights into related mechanisms. Here, a synergistic nanodepot based on a bioactive core–shell CaF2 upconversion nanostructure that integrates multiple mineral ions for metabolic regulation was built for the acceleration and monitoring of the biomineralization process. Multiple mineral ions released from the nanodepots can accelerate the growth of inorganic crystals and enhance the production of organic matrixes, synergistically facilitating the regeneration of bone defects in vivo. During the process, such a nanodepot can be constructed to specifically recognize osteoblasts for the monitoring of biomineralization. This nanoprobe represents an efficient strategy to promote and monitor biomineralization-related metabolic activities with applications in fundamental research, disease diagnosis, and regenerative medicine.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Bone health and osteoporosis research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Analytical Chemistry for Biological Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine (Ministry of Education), School and Hospital of Stomatology, Wuhan University, Wuhan, 430072, China

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

School of Materials Science and Engineering & National Institute for Advanced Materials, Key Laboratory of Advanced Energy Materials Chemistry, Tianjin Key Lab for Rare Earth Materials and Applications, Centre for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin, 300350, China

Funding

National Natural Science Foundation of China

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