DataVXACS NanoPaper
journal article·2020-11-24

Nanosensor-Based Flexible Electronic Assisted with Light Fidelity Communicating Technology for Volatolomics-Based Telemedicine

Han Jin, Junkan Yu, Shujing Lin, Shan Gao, Hao Yang, Hossam Haick, Changzhou Hua, Shengwei Deng, Tingqiang Yang, Yueli Liu, Wenfeng Shen, Xin Zhang, Xiaowei Zhang, Shan Shan, Tao Ren, Liwei Wang, Waifung Cheung, Wanlung Kam, Jianmin Miao, Di Chen, Daxiang Cui

ACS Nano· Volume 14· Issue 11
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Source abstract

Abstract

Telemedicine provides an attractive vision for tele-monitoring human health conditions and, thus, offers the opportunity for timely preventing chronic disease. A key limitation of promoting telemedicine in clinic application is the lack of a noninvasive med-tech and effective monitoring platform, which should be wearable and capable of high-performance tele-monitoring of health risk. Here we proposed a volatolomics-based telemedicine for continuously and noninvasively assessing human health status through continuously tracking the variation of volatile markers derived from human breath or skin. Particularly, a nanosensor-based flexible electronic was specifically designed to serve as a powerful platform for implementing the proposed cost-effective healthcare. An all-flexible and highly packed makeup (all functional units were integrated in a 2*2*0.19 cm3 plate) enables an electronic, compact configuration and the capability of resisting negative impact derived from customers’ daily movement. Notably, the nanosensor-based electronic demonstrates high specificity, quick response rate (t90% = 4.5 s), and desirable low detection limit (down to 0.117 ppm) in continuous tele-monitoring chronic-disease-related volatile marker (e.g., acetone). Assisted by the power saved light fidelity (Li-Fi) communicating technology, a clinic proof on the specifically designed electronic for noninvasively and uninterrupted assessing potential health risk (e.g., diabetics) is successfully implemented, with the accuracy of around 81%. A further increase in the accuracy of prewarning is predicted by excluding the impact of individual differences such as the gender, age, and smoking status of the customer. These promising pilot results indicate a bright future for the tailor-made nanosensing-device-supported volatolomics-based telemedicine in preventing chronic diseases and increasing patients’ survival rate.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Chemical Sensor Technologies · Advanced Sensor and Energy Harvesting Materials · Gas Sensing Nanomaterials and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Micro-Nano Science and Technology, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

National Engineering Research Center for Nanotechnology, Shanghai 200241, P. R. China

School of of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, P. R. China

State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, P. R. China

The Department of Chemical Engineering and The Russell Berrie Nanotechnology Institute, Technion − Israel Institute of Technology, Haifa 3200003, Israel

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China

State Key Laboratory of Silicate Materials for Architectures, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

Ningbo Materials Science and Technology Institute, Chinese Academy of Sciences, Ningbo 315201, P. R. China

Department of Respiration Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, P. R. China

School of Marine Sciences, Guangxi University, Nanning 530004, P. R. China

Qi Diagnostics Ltd, Hong Kong, P. R. China

Funding

Natural Science Foundation of Shanghai · Shanghai Jiao Tong University · Natural Science Foundation of Ningbo · Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Shanghai Municipal Bureau of Economy and Information Technology · State Key Laboratory of Bioelectronics, Southeast University

References (40)

Show source-provided references
1. 10.1016/j.pcad.2015.09.00410.1016/j.pcad.2015.09.004 ↗
2. 10.1016/S0140-6736(13)62224-210.1016/S0140-6736(13)62224-2 ↗
3. 10.1016/S0140-6736(15)60647-X10.1016/S0140-6736(15)60647-X ↗
4. 10.1016/S0140-6736(16)32064-510.1016/S0140-6736(16)32064-5 ↗
5. 10.1016/S0140-6736(05)67341-210.1016/S0140-6736(05)67341-2 ↗
6. 10.1016/S0140-6736(14)60648-610.1016/S0140-6736(14)60648-6 ↗
7. 10.1016/S0140-6736(07)61696-110.1016/S0140-6736(07)61696-1 ↗
8. 10.1016/j.bspc.2014.03.00410.1016/j.bspc.2014.03.004 ↗
9. 10.1007/s00484-013-0687-210.1007/s00484-013-0687-2 ↗
10. 10.1016/j.irbm.2014.07.00210.1016/j.irbm.2014.07.002 ↗
11. 10.1002/anie.20150015310.1002/anie.201500153 ↗
12. 10.1038/srep0461110.1038/srep04611 ↗
13. 10.1021/acs.nanolett.6b0106610.1021/acs.nanolett.6b01066 ↗
14. 10.1021/acsnano.6b0493010.1021/acsnano.6b04930 ↗
15. 10.1016/j.snb.2016.05.13510.1016/j.snb.2016.05.135 ↗
16. 10.1021/acssensors.9b0028910.1021/acssensors.9b00289 ↗
17. 10.1007/s40820-018-0228-y10.1007/s40820-018-0228-y ↗
18. 10.1016/j.chemosphere.2018.04.15410.1016/j.chemosphere.2018.04.154 ↗
19. 10.1016/j.procs.2015.04.19510.1016/j.procs.2015.04.195 ↗
20. 10.1016/j.nanoen.2017.08.06010.1016/j.nanoen.2017.08.060 ↗
21. Khandal D. · International Journal of Information and Computation Technology · 2014 · 4 · 1687
22. 10.1016/j.snb.2009.08.05310.1016/j.snb.2009.08.053 ↗
23. 10.1021/am300835p10.1021/am300835p ↗
24. 10.1039/C7RA04569G10.1039/C7RA04569G ↗
25. 10.1021/am201369510.1021/am2013695 ↗
26. 10.1103/PhysRevB.47.55810.1103/PhysRevB.47.558 ↗
27. 10.1039/C4RA10942B10.1039/C4RA10942B ↗
28. 10.1088/0957-4484/21/23/23550110.1088/0957-4484/21/23/235501 ↗
29. 10.1016/j.materresbull.2012.03.04610.1016/j.materresbull.2012.03.046 ↗
30. 10.1023/A:101440581137110.1023/A:1014405811371 ↗
31. 10.1016/j.cplett.2011.06.04510.1016/j.cplett.2011.06.045 ↗
32. 10.1088/1752-7163/aa66d310.1088/1752-7163/aa66d3 ↗
33. 10.1016/j.aca.2004.12.01810.1016/j.aca.2004.12.018 ↗
34. 10.1016/S1570-0232(04)00657-910.1016/S1570-0232(04)00657-9 ↗
35. 10.1016/j.talanta.2013.12.02510.1016/j.talanta.2013.12.025 ↗
36. 10.1088/1752-7155/7/3/03710910.1088/1752-7155/7/3/037109 ↗
37. 10.1021/nn201864910.1021/nn2018649 ↗
38. 10.1021/acsnano.6b0144110.1021/acsnano.6b01441 ↗
39. 10.1039/C5RA06529A10.1039/C5RA06529A ↗
40. 10.1109/TMTT.2009.201728810.1109/TMTT.2009.2017288 ↗