DataVXACS NanoPaper
journal article·2019-09-24

Dynamic and Hierarchically Structured Networks with Tissue-like Mechanical Behavior

Chaoxi Wu, Jintao Huang, Bin Chu, Jianping Deng, Zhen Zhang, Shunqing Tang, Xiaoying Wang, Zhiping Wang, Yifei Wang

ACS Nano· Volume 13· Issue 9
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Source abstract

Abstract

Collagen is the most abundant structural protein in soft tissues, and the duplication of its structure and mechanics represents a key challenge to nanotechnology. Here we report a fibrous supramolecular network that can mimic nearly all of the aspects of collagen from dynamic hierarchical architecture to nonlinear mechanical behavior. This complex self-assembly system is solely based on a glucose polymer: curdlan, which is synthesized by bacteria and can form a similar triple helix as collagen. Triggered by solvent and temperature cues, free curdlan chains wind into superhelical trimers, and the trimers then bundle hexagonally into nanofibers of 20-40 nm in diameter. The fibers are interconnected in a water-rich 3D network structure. The network is highly dynamic and stress-responsive, which can shift from isotropic to anisotropic organization by the winding/unwinding of stress-induced interfiber triple helical net-points. Mechanical tests show that these nanofiber networks exhibit similar nonlinear elasticity as collagenous tissues including skin and tendon. The supramolecular networks also display a very wide range of tensile strength from ∼60 KPa to ∼50 MPa depending on the specific network organization. These biomimetic and dynamic supernetworks may have applications in tissue engineering, drug delivery systems, artificial skin, and soft robotics.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Collagen: Extraction and Characterization · Hydrogels: synthesis, properties, applications · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China

Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China

Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, China

Key Laboratory of Biomedical Materials and Implants, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China

Biomedical Engineering Institute, Jinan University, Guangzhou, 510632, China

Funding

Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Science and Technology Foundation of Shenzhen · Marine Fishery Science and Technology Promotion Project of Guangdong · Science and Technology Plan Projects of Guangzhou · Marine Economy Innovation and Development Project · Pearl River S&T Nova Program of Guangzhou · Guangdong Science and Technology Program Funding Project

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