journal article·2015-02-24

Hierarchical Patterning of Multifunctional Conducting Polymer Nanoparticles as a Bionic Platform for Topographic Contact Guidance

Dominic Ho, Jianli Zou, Xianjue Chen, Alaa Munshi, Nicole M. Smith, Vipul Agarwal, Stuart I. Hodgetts, Giles W. Plant, Anthony J. Bakker, Alan R. Harvey, Igor Luzinov, K. Swaminathan Iyer

ACS Nano· Volume 9· Issue 2
Publisher page

Abstract

The use of programmed electrical signals to influence biological events has been a widely accepted clinical methodology for neurostimulation. An optimal biocompatible platform for neural activation efficiently transfers electrical signals across the electrode-cell interface and also incorporates large-area neural guidance conduits. Inherently conducting polymers (ICPs) have emerged as frontrunners as soft biocompatible alternatives to traditionally used metal electrodes, which are highly invasive and elicit tissue damage over long-term implantation. However, fabrication techniques for the ICPs suffer a major bottleneck, which limits their usability and medical translation. Herein, we report that these limitations can be overcome using colloidal chemistry to fabricate multimodal conducting polymer nanoparticles. Furthermore, we demonstrate that these polymer nanoparticles can be precisely assembled into large-area linear conduits using surface chemistry. Finally, we validate that this platform can act as guidance conduits for neurostimulation, whereby the presence of electrical current induces remarkable dendritic axonal sprouting of cells.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Neuroscience and Neural Engineering · Conducting polymers and applications · Nerve injury and regeneration

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia 6009, Australia

School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia

Institute for Integrated Cell-Material Sciences (iCeMS), iCeMS Complex 2, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan

Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia

Stanford Partnership for Spinal Cord Injury and Repair, Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, United States

School of Materials Science and Engineering, Clemson University, Clemson, South Carolina 29634, United States

Funding

State and Commonwealth Governments · The University of Western Australia · Australian Research Council · Division of Chemical, Bioengineering, Environmental, and Transport Systems · National Health and Medical Research Council

References (30)

Show source-provided references
1. Ciofani G. · ACS Nano · 2010 · 4 · 626710.1021/nn101985a ↗
2. Moulton S. E. · Adv. Funct. Mater. · 2012 · 22 · 200310.1002/adfm.201102232 ↗
3. Wallace G. G. · Science · 2009 · 324 · 18510.1126/science.1168346 ↗
4. Wallace G. G. · Nanoscale · 2012 · 4 · 432710.1039/c2nr30758h ↗
5. Khademhosseini A. · Proc. Natl. Acad. Sci. U.S.A. · 2006 · 103 · 248010.1073/pnas.0507681102 ↗
6. Guimard N. K. · Prog. Polym. Sci. · 2007 · 32 · 87610.1016/j.progpolymsci.2007.05.012 ↗
7. Kim D. H. · Adv. Funct. Mater. · 2007 · 17 · 7910.1002/adfm.200500594 ↗
8. Lee J. I. · Nano Lett. · 2008 · 8 · 231510.1021/nl801105s ↗
9. Wang J. · Nat. Mater. · 2004 · 3 · 17110.1038/nmat1073 ↗
10. Nakashima H. · Langmuir · 2011 · 28 · 80410.1021/la203356s ↗
11. Iyer K. S. · Macromolecules · 2003 · 36 · 651910.1021/ma034460z ↗
12. Zou J. · Chem. Commun. · 2012 · 48 · 103310.1039/C1CC15522A ↗
13. Choi J. · Synth. Met. · 2010 · 160 · 141510.1016/j.synthmet.2010.04.021 ↗
14. Merrill D. R. · J. Neurosci. Methods · 2005 · 141 · 17110.1016/j.jneumeth.2004.10.020 ↗
15. Chen C. S. · Biotechnol. Prog. · 1998 · 14 · 35610.1021/bp980031m ↗
16. Ito Y. · Biomaterials · 1999 · 20 · 233310.1016/S0142-9612(99)00162-3 ↗
17. Schmidt C. E. · Proc. Natl. Acad. Sci. U.S.A. · 1997 · 94 · 894810.1073/pnas.94.17.8948 ↗
18. Richardson R. T. · Biomaterials · 2007 · 28 · 51310.1016/j.biomaterials.2006.09.008 ↗
19. Weng B. · Synth. Met. · 2012 · 162 · 137510.1016/j.synthmet.2012.05.022 ↗
20. Wong J. Y. · Proc. Natl. Acad. Sci. U.S.A. · 1994 · 91 · 320110.1073/pnas.91.8.3201 ↗
21. Bourguignon G. · FASEB J. · 1987 · 1 · 39810.1096/fasebj.1.5.3678699 ↗
22. Al-Majed A. A. · J. Neurosci. · 2000 · 20 · 260210.1523/JNEUROSCI.20-07-02602.2000 ↗
23. Brushart T. M. · Exp. Neurol. · 2005 · 194 · 22110.1016/j.expneurol.2005.02.007 ↗
24. Brushart T. M. · J. Neurosci. · 2002 · 22 · 663110.1523/JNEUROSCI.22-15-06631.2002 ↗
25. Franz C. K. · Brain · 2008 · 131 · 149210.1093/brain/awn039 ↗
26. Eberhardt K. A. · Exp. Neurol. · 2006 · 198 · 50010.1016/j.expneurol.2005.12.018 ↗
27. Geremia N. M. · Exp. Neurol. · 2007 · 205 · 34710.1016/j.expneurol.2007.01.040 ↗
28. Yan X. · Neurochem. Res. · 2014 · 39 · 12910.1007/s11064-013-1197-7 ↗
29. Das K. P. · Neurotoxicol. Teratol. · 2004 · 26 · 39710.1016/j.ntt.2004.02.006 ↗
30. Drubin D. G. · J. Cell Biol. · 1985 · 101 · 179910.1083/jcb.101.5.1799 ↗