Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

Yekkuni L. Balachandran; Wei Wang; Hongyi Yang; Haiyang Tong; Lulu Wang; Feng Liu; Hongsong Chen; Kai Zhong; Ye Liu; Xingyu Jiang

doi:10.1021/acsnano.1c10618

journal article·2022-04-26

Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

Yekkuni L. Balachandran, Wei Wang, Hongyi Yang, Haiyang Tong, Lulu Wang, Feng Liu, Hongsong Chen, Kai Zhong, Ye Liu, Xingyu Jiang

ACS Nano· Volume 16· Issue 4

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Source abstract

Abstract

Challenges remain in precisely diagnosing the progress of liver fibrosis in a noninvasive way. We here synthesized small (4 nm) heterogeneous iron oxide/dysprosium oxide nanoparticles (IO-DyO NPs) as a contrast agent (CA) for magnetic resonance imaging (MRI) to precisely diagnose liver fibrosis in vivo at both 7.0 and 9.4 T field strength. Our IO-DyO NPs can target the liver and show an increased T2 relaxivity along with an increase of magnetic field strength. At a ultrahigh magnetic field, IO-DyO NPs can significantly improve spatial/temporal image resolution and signal-to-noise ratio of the liver and precisely distinguish the early and moderate liver fibrosis stages. Our IO-DyO NP-based MRI diagnosis can exactly match biopsy (a gold standard for liver fibrosis diagnosis in the clinic) but avoid the invasiveness of biopsy. Moreover, our IO-DyO NPs show satisfactory biosafety in vitro and in vivo. This work illustrates an advanced T2 CA used in ultrahigh-field MRI (UHFMRI) for the precise diagnosis of liver fibrosis via a noninvasive means.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Liver Disease Diagnosis and Treatment · Liver Disease and Transplantation · Hepatocellular Carcinoma Treatment and Prognosis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, China

Peking University People’s Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Beijing 100044, China

High Field Magnetic Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650000, China

Funding

Ministry of Science and Technology of the People's Republic of China · Tencent · National Natural Science Foundation of China · Chinese Academy of Sciences · Health Commission of Yunnan Province · Yunnan Province

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