journal article·2019-05-28Open access

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

Angela F. De Fazio, Afaf H. El-Sagheer, Jason S. Kahn, Iris Nandhakumar, Matthew Richard Burton, Tom Brown, Otto L. Muskens, Oleg Gang, Antonios G. Kanaras

ACS Nano· Volume 13· Issue 5

Abstract

DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. The oligonucleotides attached to the nanoparticles are encoded to ligate using 365 nm light, effectively locking the SLs and rendering them stable under DNA denaturing conditions. The reversible process of unlocking these structures is possible by irradiation with light at 315 nm, recovering the structures to their natural state. Our work inspires an alternative research direction toward postassembly manipulation of nanoparticle superstructures using external stimuli as a tool to enrich the library of additional material forms and their application in different media and environments.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, U.K.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, U.K.

Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt

Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, United States

Department of Chemical Engineering, Columbia University, New York, New York 10027, United States

School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, U.K.

SPECIFIC-IKC, Materials Research Centre, College of Engineering, Swansea University, Bay Campus, Fabian Way, Swansea, SA1 8EN, U.K.

Institute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, U.K.

Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, United States

Funding

Engineering and Physical Sciences Research Council · Basic Energy Sciences · Defence Science and Technology Laboratory · Biotechnology and Biological Sciences Research Council

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