DataVXACS NanoPaper
journal article·2017-01-24

Single Plasmonic Nanosprings for Visualizing Reactive-Oxygen-Species-Activated Localized Mechanical Force Transduction in Live Cells

Bin Xiong, Zhenrong Huang, Hongyan Zou, Chunyan Qiao, Yan He, Edward S. Yeung

ACS Nano· Volume 11· Issue 1
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Source abstract

Abstract

Mechanical force signaling in cells has been regarded as the biological foundation of various important physiological functions. To understand the nature of these biological and physiological processes, imaging and determining the mechanical signal transduction dynamics in live cells are required. Herein, we proposed a strategy to determine mechanical force as well as its changes with single-particle dark-field spectral microscopy by using a single plasmonic nanospring as a mechanical sensor, which can transfer force-induced molecular extension/compression into spectral responses. With this robust plasmonic nanospring, we achieved the visualization of activation of localized mechanical force transduction in single live cells triggered by reactive-oxygen-species (ROS) stimulation. The successful demonstration of a biochemical ROS signal to mechanical signal conversion suggested this strategy is promising for studying mechanical force signaling and regulation in live biological systems.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Mechanical and Optical Resonators · Force Microscopy Techniques and Applications · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, People’s Republic of China

Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People’s Republic of China

Department of Chemistry, Tsinghua University, Beijing, 100084, People’s Republic of China

Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States

Funding

Ministry of Education of the People's Republic of China · Natural Science Foundation of Hunan Province · Hunan University · National Natural Science Foundation of China · State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, Hunan University

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