Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping

Stefan Howorka; Zuzanna Siwy

doi:10.1021/acsnano.6b07041

journal article·2016-11-22Open access

Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping

Stefan Howorka, Zuzanna Siwy

ACS Nano· Volume 10· Issue 11

Publisher page Open full text

Source abstract

Abstract

DNA strands can be analyzed at the single-molecule level by isolating them inside nanoscale holes. The strategy is used for the label-free and portable sequencing with nanopores. Nanochannels can also be applied to map genomes with high resolution, as shown by Jeffet et al. in this issue of ACS Nano. Here, we compare the two strategies in terms of biophysical similarities and differences and describe that both are complementary and can improve the DNA analysis for genomic research and diagnostics.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Institute of Structural Molecular Biology, University College London, London WC1H 0AJ, United Kingdom

Department of Physics and Astronomy, University of California, Irvine, 210G Rowland Hall, Irvine, California 92697, United States

Funding

Engineering and Physical Sciences Research Council · Biotechnology and Biological Sciences Research Council · National Science Foundation

References (14)

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