Coagulation-Inspired Direct Fibrinogen Assay Using Plasmonic Nanoparticles Functionalized with Red Blood Cell Membranes
Source abstract
Abstract
The fast measurement of fibrinogen is essential in evaluating life-threatening sepsis and cardiovascular diseases. Here, we aim to utilize biomimetic plasmonic Au nanoparticles using red blood cell membranes (RBCM-AuNPs) and demonstrate nanoscale coagulation-inspired fibrinogen detection via cross-linking between RBCM-AuNPs. The proposed biomimetic RBCM-AuNPs are highly suitable for fibrinogen detection because hemagglutination, occurring in the presence of fibrinogen, induces a shift in the localized surface plasmon resonance of the NPs. Specifically, when the two ends of the fibrinogen protein are bound to receptors on separate RBCM-AuNPs, cross-linking of the RBCM-AuNPs occurs, yielding a corresponding plasmon shift within 10 min. This coagulation-inspired fibrinogen detection method, with a low sample volume, high selectivity, and high speed, could facilitate the diagnosis of sepsis and cardiovascular diseases.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Blood properties and coagulation · Erythrocyte Function and Pathophysiology · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea
Department of Electrical Engineering, Kwangwoon University, Seoul 01897, Republic of Korea
Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea
Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology, Korea University, Sejong 30019, Republic of Korea
Interdisciplinary Program in Precision Public Health, Korea University, Seoul 02841, Republic of Korea
Funding
Kwangwoon University · Ministry of Education · National Research Foundation of Korea
References (43)
Show source-provided references
1. 10.1161/01.CIR.0000052939.59093.4510.1161/01.CIR.0000052939.59093.45 ↗
2. 10.1164/rccm.201504-0781OC10.1164/rccm.201504-0781OC ↗
3. 10.1038/s41551-018-0288-910.1038/s41551-018-0288-9 ↗
4. 10.1016/j.thromres.2019.07.00210.1016/j.thromres.2019.07.002 ↗
5. 10.1097/ACO.000000000000016310.1097/ACO.0000000000000163 ↗
6. 10.1055/s-0030-124872010.1055/s-0030-1248720 ↗
7. 10.1111/j.1365-2796.1990.tb00157.x10.1111/j.1365-2796.1990.tb00157.x ↗
8. 10.1097/MOH.0b013e328364219d10.1097/MOH.0b013e328364219d ↗
9. 10.11909/j.issn.1671-5411.2017.02.00810.11909/j.issn.1671-5411.2017.02.008 ↗
10. 10.1046/j.1365-2141.2003.04256.x10.1046/j.1365-2141.2003.04256.x ↗
11. 10.1097/TA.000000000000238510.1097/TA.0000000000002385 ↗
12. 10.1038/2031184a010.1038/2031184a0 ↗
13. 10.1001/jama.1987.0340009006703510.1001/jama.1987.03400090067035 ↗
14. 10.1001/jama.294.14.179910.1001/jama.294.14.1799 ↗
15. 10.1002/adma.20170675910.1002/adma.201706759 ↗
16. 10.1002/adma.20130063810.1002/adma.201300638 ↗
17. 10.1039/c3nr03064d10.1039/c3nr03064d ↗
18. 10.1038/nature1537310.1038/nature15373 ↗
19. 10.1038/s41565-018-0254-410.1038/s41565-018-0254-4 ↗
20. 10.1021/nl500618u10.1021/nl500618u ↗
21. 10.1016/j.bios.2017.12.00210.1016/j.bios.2017.12.002 ↗
22. 10.1016/j.bios.2019.04.00710.1016/j.bios.2019.04.007 ↗
23. 10.1038/nnano.2016.5210.1038/nnano.2016.52 ↗
24. 10.1021/nn100964810.1021/nn1009648 ↗
25. 10.1046/j.1365-2141.2003.04256.x10.1046/j.1365-2141.2003.04256.x ↗
26. 10.1038/nprot.2008.14910.1038/nprot.2008.149 ↗
27. 10.1021/nl080080l10.1021/nl080080l ↗
28. 10.1016/j.surfrep.2006.06.00110.1016/j.surfrep.2006.06.001 ↗
29. 10.1016/j.jconrel.2016.06.01710.1016/j.jconrel.2016.06.017 ↗
30. 10.1039/C3NR05444F10.1039/C3NR05444F ↗
31. 10.1146/annurev.physchem.58.032806.10460710.1146/annurev.physchem.58.032806.104607 ↗
32. 10.1016/j.bios.2019.04.03010.1016/j.bios.2019.04.030 ↗
33. 10.1016/j.snb.2019.05.01610.1016/j.snb.2019.05.016 ↗
34. 10.1038/s41563-019-0323-610.1038/s41563-019-0323-6 ↗
35. 10.1111/j.1472-8206.2008.00633.x10.1111/j.1472-8206.2008.00633.x ↗
36. 10.1111/j.1432-1033.1975.tb03931.x10.1111/j.1432-1033.1975.tb03931.x ↗
37. 10.1021/acs.langmuir.7b0425210.1021/acs.langmuir.7b04252 ↗
38. 10.1021/ja02242a00410.1021/ja02242a004 ↗
39. 10.1016/0166-6622(92)80043-210.1016/0166-6622(92)80043-2 ↗
40. 10.1021/acsnano.6b0485810.1021/acsnano.6b04858 ↗
41. 10.1016/j.bios.2017.12.00210.1016/j.bios.2017.12.002 ↗
42. 10.1016/j.bios.2016.11.00210.1016/j.bios.2016.11.002 ↗
43. 10.1126/scitranslmed.aax015310.1126/scitranslmed.aax0153 ↗