journal article·2016-03-22

Polyvinylpyrrolidone–Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine

Ye Liu, Yekkuni L Balachandran, Dan Li, Yiming Shao, Xingyu Jiang

ACS Nano· Volume 10· Issue 3
Publisher page

Abstract

One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic.
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Research context

OpenAlex topics: HIV Research and Treatment · Immunotherapy and Immune Responses · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Number 11 Zhongguancun Beiyitiao, Beijing 100190, China

State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100190, China

Center of Infectious Diseases, Peking University, Beijing 100190, China

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310027, China

School of Medicine, Nankai University, Tianjin 300071, China

Funding

Ministry of Health of the People's Republic of China · CAS-SAFEA International Partnership Program for Creative Research Teams · National Natural Science Foundation of China · Chinese Academy of Sciences

References (39)

Show source-provided references
1. 10.1016/S0140-6736(14)60164-110.1016/S0140-6736(14)60164-1 ↗
2. 10.1002/smll.20140170710.1002/smll.201401707 ↗
3. 10.3390/ma606229510.3390/ma6062295 ↗
4. 10.1039/c4nr00843j10.1039/c4nr00843j ↗
5. 10.3109/17435390.2014.90745710.3109/17435390.2014.907457 ↗
6. 10.1021/nn100816s10.1021/nn100816s ↗
7. 10.1002/adma.20130568310.1002/adma.201305683 ↗
8. 10.1021/nl052396o10.1021/nl052396o ↗
9. 10.1021/acsnano.5b0215310.1021/acsnano.5b02153 ↗
10. 10.1084/jem.161.6.135710.1084/jem.161.6.1357 ↗
11. 10.1016/j.biomaterials.2013.03.02410.1016/j.biomaterials.2013.03.024 ↗
12. 10.1021/ja102884310.1021/ja1028843 ↗
13. 10.1088/0957-4484/19/23/23510410.1088/0957-4484/19/23/235104 ↗
14. 10.1021/bm034193510.1021/bm0341935 ↗
15. 10.1002/anie.20100296910.1002/anie.201002969 ↗
16. 10.1039/C4NR05781C10.1039/C4NR05781C ↗
17. 10.1039/b510984a10.1039/b510984a ↗
18. 10.1016/j.toxlet.2013.02.01010.1016/j.toxlet.2013.02.010 ↗
19. 10.1039/c3nr06386k10.1039/c3nr06386k ↗
20. 10.1021/jz400501510.1021/jz4005015 ↗
21. 10.1016/j.toxlet.2011.11.00210.1016/j.toxlet.2011.11.002 ↗
22. 10.1146/annurev-virology-031413-08543710.1146/annurev-virology-031413-085437 ↗
23. 10.1038/nnano.2012.20710.1038/nnano.2012.207 ↗
24. 10.1002/adma.20140478810.1002/adma.201404788 ↗
25. 10.1016/j.jconrel.2014.06.03810.1016/j.jconrel.2014.06.038 ↗
26. 10.1007/s11033-012-1792-810.1007/s11033-012-1792-8 ↗
27. 10.1039/C1CS15188F10.1039/C1CS15188F ↗
28. 10.2217/nnm.11.7810.2217/nnm.11.78 ↗
29. 10.1056/NEJMoa111342510.1056/NEJMoa1113425 ↗
30. 10.1182/blood-2008-09-17975410.1182/blood-2008-09-179754 ↗
31. 10.1038/mi.2012.910.1038/mi.2012.9 ↗
32. 10.1182/blood-2005-12-481810.1182/blood-2005-12-4818 ↗
33. 10.1182/blood-2012-04-42255010.1182/blood-2012-04-422550 ↗
34. 10.1016/j.jaut.2014.04.00110.1016/j.jaut.2014.04.001 ↗
35. 10.1128/JVI.02032-1410.1128/JVI.02032-14 ↗
36. 10.2165/00063030-200115120-0000510.2165/00063030-200115120-00005 ↗
37. 10.2147/IJN.S4409010.2147/IJN.S44090 ↗
38. 10.1016/S1473-3099(11)70099-810.1016/S1473-3099(11)70099-8 ↗
39. 10.1038/nri370510.1038/nri3705 ↗