journal article·2011-12-27

Iron Oxide Nanoparticle-Induced Epidermal Growth Factor Receptor Expression in Human Stem Cells for Tumor Therapy

Tsai-Hua Chung, Jong-Kai Hsiao, Szu-Chun Hsu, Ming Yao, Yao-Chang Chen, Shih-Wei Wang, Mark Yen-Ping Kuo, Chung-Shi Yang, Dong-Ming Huang

ACS Nano· Volume 5· Issue 12
Publisher page

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles show promise as labels for cellular magnetic resonance imaging (MRI) in the application of stem cell-based therapy. However, the unaddressed concerns about the impact of SPIO nanoparticles on stem cell attributes make the feasibility of SPIO labeling uncertain. Here, we show that the labeling of human mesenchymal stem cells (hMSCs) with ferucarbotran can induce epidermal growth factor receptor (EGFR) overexpression. Labeled hMSCs with their overexpressed EGFR were attracted by tumorous EGF and more effectively migrated toward tumor than unlabeled cells, resulting in more potent intrinsic antitumor activity. Moreover, the captured binding of tumorous EGF by overexpressed EGFR of labeled hMSCs blocked EGF/EGFR signaling-derived tumor growth, tumorous angiogenesis, and tumorous VEGF expression also responsible for tumor progression and development. Our results show that the impact of SPIO nanoparticles on stem cell attributes is not necessarily harmful but can be cleverly used to be beneficial to stem cell-based therapy.
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Research context

OpenAlex topics: Cancer Cells and Metastasis · Cancer-related Molecular Pathways · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Nanomedicine Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China

Graduate Institute of Clinical Dentistry School of Dentistry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Department of Medical Imaging, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Taiwan, Republic of China

Department of Laboratory Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, Republic of China

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