DataVXACS NanoPaper
journal article·2020-01-28Open access

Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Julie T.-W. Wang, Rebecca Klippstein, Markus Martincic, Elzbieta Pach, Robert Feldman, Martin Šefl, Yves Michel, Daniel Asker, Jane K. Sosabowski, Martin Kalbac, Tatiana Da Ros, Cécilia Ménard-Moyon, Alberto Bianco, Ioanna Kyriakou, Dimitris Emfietzoglou, Jean-Claude Saccavini, Belén Ballesteros, Khuloud T. Al-Jamal, Gerard Tobias

ACS Nano· Volume 14· Issue 1
Publisher pageOpen full text
Source abstract

Abstract

Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nanotubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing “cold” isotopically enriched samarium (152Sm), which can then be activated on demand to their “hot” radioactive form (153Sm) by neutron irradiation. The use of “cold” isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the “hot” nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Boron Compounds in Chemistry · Radiation Therapy and Dosimetry · Nuclear Physics and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, United Kingdom

Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 Bellaterra, Barcelona, Spain

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, 08193 Bellaterra, Barcelona, Spain

Cis Bio International Ion Beam Applications SA, Gif sur Yvette 91192, France

Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110, Greece

Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Prague 11519, Czech Republic

Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom

J. Heyrovsky Institute of the Physical Chemistry, Dolejskova 3, 182 23 Prague 8, Czech Republic

INSTM Unit of Trieste, Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy

CNRS, Immunology, Immunopathology and Therapeutic Chemistry, University of Strasbourg, UPR 3572, 67000 Strasbourg, France

Funding

Agence Nationale de la Recherche · Worldwide Cancer Research · Ministerstvo ?kolství, Mláde?e a Telovýchovy · Ministerio de Economía y Competitividad · Centre International de Recherche aux Frontières de la Chimie · Centre National de la Recherche Scientifique · Agència de Gestió d'Ajuts Universitaris i de Recerca

References (86)

Show source-provided references
1. 10.1021/acsnano.7b0510810.1021/acsnano.7b05108 ↗
2. 10.1021/acsnano.8b0774610.1021/acsnano.8b07746 ↗
3. 10.1021/acsnano.8b0368410.1021/acsnano.8b03684 ↗
4. 10.1021/acsnano.7b0485510.1021/acsnano.7b04855 ↗
5. 10.1021/acs.nanolett.8b0234010.1021/acs.nanolett.8b02340 ↗
6. 10.1021/acs.chemrev.5b0000810.1021/acs.chemrev.5b00008 ↗
7. 10.1021/acscentsci.6b0000510.1021/acscentsci.6b00005 ↗
8. 10.1016/j.biomaterials.2016.05.04510.1016/j.biomaterials.2016.05.045 ↗
9. 10.1002/adma.20180236810.1002/adma.201802368 ↗
10. 10.1002/open.20170018410.1002/open.201700184 ↗
11. 10.1039/c1nr10080g10.1039/c1nr10080g ↗
12. 10.1016/j.biomaterials.2015.02.08310.1016/j.biomaterials.2015.02.083 ↗
13. 10.1002/anie.20046043710.1002/anie.200460437 ↗
14. 10.1002/ange.20046043710.1002/ange.200460437 ↗
15. 10.1016/j.addr.2013.07.00610.1016/j.addr.2013.07.006 ↗
16. 10.1039/C6NR06728J10.1039/C6NR06728J ↗
17. 10.1039/C3NJ01008B10.1039/C3NJ01008B ↗
18. 10.1021/am302902d10.1021/am302902d ↗
19. 10.1021/ar300106h10.1021/ar300106h ↗
20. 10.1021/acsnano.8b0618910.1021/acsnano.8b06189 ↗
21. 10.1021/acsnano.8b0144010.1021/acsnano.8b01440 ↗
22. 10.1021/acsnano.9b0185710.1021/acsnano.9b01857 ↗
23. 10.1021/acsnano.8b0563910.1021/acsnano.8b05639 ↗
24. 10.1021/acs.molpharmaceut.8b0085210.1021/acs.molpharmaceut.8b00852 ↗
25. 10.1038/nmat276610.1038/nmat2766 ↗
26. 10.1038/nmat277610.1038/nmat2776 ↗
27. 10.1016/j.chempr.2017.06.01310.1016/j.chempr.2017.06.013 ↗
28. 10.1016/j.ica.2019.05.03210.1016/j.ica.2019.05.032 ↗
29. 10.1016/j.carbon.2006.06.01010.1016/j.carbon.2006.06.010 ↗
30. 10.1016/j.carbon.2018.10.00610.1016/j.carbon.2018.10.006 ↗
31. 10.1021/acssuschemeng.6b0285010.1021/acssuschemeng.6b02850 ↗
32. 10.1038/ncomms1311810.1038/ncomms13118 ↗
33. 10.1002/adma.20170099610.1002/adma.201700996 ↗
34. 10.1016/j.addr.2016.08.00110.1016/j.addr.2016.08.001 ↗
35. 10.1016/j.biomaterials.2016.12.01010.1016/j.biomaterials.2016.12.010 ↗
36. 10.1021/acsnano.7b0725210.1021/acsnano.7b07252 ↗
37. 10.1073/pnas.050900910310.1073/pnas.0509009103 ↗
38. 10.1371/journal.pone.000090710.1371/journal.pone.0000907 ↗
39. 10.2147/IJN.S1330010.2147/IJN.S13300 ↗
40. 10.1002/smll.20070015310.1002/smll.200700153 ↗
41. 10.2217/nnm.14.2610.2217/nnm.14.26 ↗
42. 10.2967/jnumed.115.15831110.2967/jnumed.115.158311 ↗
43. 10.1002/adma.20070229210.1002/adma.200702292 ↗
44. 10.1039/b800881g10.1039/b800881g ↗
45. Bayouth J. E. · J. Nucl. Med. · 1994 · 35 · 63
46. 10.1016/j.apradiso.2011.11.05610.1016/j.apradiso.2011.11.056 ↗
47. 10.1517/14656566.7.11.147510.1517/14656566.7.11.1475 ↗
48. 10.1371/journal.pone.013810610.1371/journal.pone.0138106 ↗
49. 10.1080/0363904080191862310.1080/03639040801918623 ↗
50. 10.1007/s11095-010-0226-310.1007/s11095-010-0226-3 ↗
51. 10.1002/smll.20110248810.1002/smll.201102488 ↗
52. 10.1021/ja960841z10.1021/ja960841z ↗
53. 10.1073/pnas.96.9.518210.1073/pnas.96.9.5182 ↗
54. 10.2967/jnumed.112.10660910.2967/jnumed.112.106609 ↗
55. 10.1016/j.ica.2012.06.01610.1016/j.ica.2012.06.016 ↗
56. 10.1063/1.489911810.1063/1.4899118 ↗
57. 10.1021/acs.molpharmaceut.5b0030410.1021/acs.molpharmaceut.5b00304 ↗
58. 10.1016/j.carbon.2017.02.08510.1016/j.carbon.2017.02.085 ↗
59. 10.1016/j.nucmedbio.2017.05.00910.1016/j.nucmedbio.2017.05.009 ↗
60. 10.1016/S1470-2045(12)70334-010.1016/S1470-2045(12)70334-0 ↗
61. 10.1007/s00270-018-2133-710.1007/s00270-018-2133-7 ↗
62. 10.1016/j.carbon.2018.06.02110.1016/j.carbon.2018.06.021 ↗
63. Manual for Reactor Produced Radioisotopes, IAEA-TECDOC-1340; IAEA: Vienna, Austria, 2003; pp 189–192.
64. Giulio C. · 2016 · 315
65. 10.1039/C5CP04664E10.1039/C5CP04664E ↗
66. 10.1063/1.291811910.1063/1.2918119 ↗
67. 10.1002/adma.20130516910.1002/adma.201305169 ↗
68. 10.1002/anie.20170358510.1002/anie.201703585 ↗
69. 10.1021/acsnano.8b0163810.1021/acsnano.8b01638 ↗
70. 10.1021/acsnano.8b0226110.1021/acsnano.8b02261 ↗
71. 10.1021/acs.nanolett.9b0013310.1021/acs.nanolett.9b00133 ↗
72. Tse J. W. · J. Nucl. Med. · 1989 · 30 · 202
73. 10.1038/newbio242148a010.1038/newbio242148a0 ↗
74. 10.1016/j.intimp.2012.09.00810.1016/j.intimp.2012.09.008 ↗
75. 10.1038/srep4260510.1038/srep42605 ↗
76. 10.1007/s00270-017-1594-410.1007/s00270-017-1594-4 ↗
77. 2014
78. 2014
79. 1999
80. 10.1016/j.poly.2016.03.04510.1016/j.poly.2016.03.045 ↗
81. 10.1016/j.mex.2018.11.00410.1016/j.mex.2018.11.004 ↗
82. 10.1118/1.494850410.1118/1.4948504 ↗
83. Stabin M. G. · J. Nucl. Med. · 2000 · 41 · 149
84. 10.1002/(SICI)1097-0215(19970207)70:4<488::AID-IJC22>3.0.CO;2-A10.1002/(SICI)1097-0215(19970207)70:4<488::AID-IJC22>3.0.CO;2-A ↗
85. Chapman J. D. · 2015
86. 10.1088/0031-9155/41/10/00110.1088/0031-9155/41/10/001 ↗