Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains

Bolin An; Xinyu Wang; Mengkui Cui; Xinrui Gui; Xiuhai Mao; Yan Liu; Ke Li; Cenfeng Chu; Jiahua Pu; Susu Ren; Yanyi Wang; Guisheng Zhong; Timothy K. Lu; Cong Liu; Chao Zhong

doi:10.1021/acsnano.7b02298

journal article·2017-07-25

Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains

Bolin An, Xinyu Wang, Mengkui Cui, Xinrui Gui, Xiuhai Mao, Yan Liu, Ke Li, Cenfeng Chu, Jiahua Pu, Susu Ren, Yanyi Wang, Guisheng Zhong, Timothy K. Lu, Cong Liu, Chao Zhong

ACS Nano· Volume 11· Issue 7

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Source abstract

Abstract

Self-assembling supramolecular nanofibers, common in the natural world, are of fundamental interest and technical importance to both nanotechnology and materials science. Despite important advances, synthetic nanofibers still lack the structural and functional diversity of biological molecules, and the controlled assembly of one type of molecule into a variety of fibrous structures with wide-ranging functional attributes remains challenging. Here, we harness the low-complexity (LC) sequence domain of fused in sarcoma (FUS) protein, an essential cellular nuclear protein with slow kinetics of amyloid fiber assembly, to construct random copolymer-like, multiblock, and self-sorted supramolecular fibrous networks with distinct structural features and fluorescent functionalities. We demonstrate the utilities of these networks in the templated, spatially controlled assembly of ligand-decorated gold nanoparticles, quantum dots, nanorods, DNA origami, and hybrid structures. Owing to the distinguishable nanoarchitectures of these nanofibers, this assembly is structure-dependent. By coupling a modular genetic strategy with kinetically controlled complex supramolecular self-assembly, we demonstrate that a single type of protein molecule can be used to engineer diverse one-dimensional supramolecular nanostructures with distinct functionalities.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China

University of Chinese Academy of Sciences, Beijing 100049, China

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032,China

Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032,China

iHuman Institute, ShanghaiTech University, Shanghai 201210, China

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Department of Electrical Engineering and Computer Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, United States

Funding

Ministry of Science and Technology of the People's Republic of China · Army Research Office · Shanghai Municipal Education Commission · Shanghai Municipal Human Resources and Social Security Bureau · Office of Naval Research · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Qingdao National Laboratory for Marine Science and Technology · Central People's Government of the People's Republic of China

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