DataVXACS NanoPaper
journal article·2016-08-23

Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

Haijun Tian, Juanjuan Du, Jing Wen, Yang Liu, Scott R. Montgomery, Trevor P. Scott, Bayan Aghdasi, Chengjie Xiong, Akinobu Suzuki, Tetsuo Hayashi, Monchai Ruangchainikom, Kevin Phan, Gil Weintraub, Alobaidaan Raed, Samuel S. Murray, Michael D. Daubs, Xianjin Yang, Xu-bo Yuan, Jeffrey C. Wang, Yunfeng Lu

ACS Nano· Volume 10· Issue 8
Publisher page
Source abstract

Abstract

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Connective tissue disorders research · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Surgery, Bethune School of Medics, Shijiazhuang 050000, China

Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Research Service, VA Greater Los Angeles Healthcare System, North Hills, California 91343, United States

Division of Orthopaedic Surgery, Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada 89102, United States

Department of Material Science, Tianjin University, Tianjin 300072, China

Department of Orthopaedic Surgery, University of Southern California, Los Angeles, California 90033, United States

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

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