DataVXACS NanoPaper
journal article·2016-04-26

Synergistic Inhibitory Effect of Peptide–Organic Coassemblies on Amyloid Aggregation

Lin Niu, Lei Liu, Wenhui Xi, Qiusen Han, Qiang Li, Yue Yu, Qunxing Huang, Fuyang Qu, Meng Xu, Yibao Li, Huiwen Du, Rong Yang, Jacob Cramer, Kurt V. Gothelf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Chen Wang, Guanghong Wei, Yanlian Yang

ACS Nano· Volume 10· Issue 4
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Source abstract

Abstract

Inhibition of amyloid aggregation is important for developing potential therapeutic strategies of amyloid-related diseases. Herein, we report that the inhibition effect of a pristine peptide motif (KLVFF) can be significantly improved by introducing a terminal regulatory moiety (terpyridine). The molecular-level observations by using scanning tunneling microscopy reveal stoichiometry-dependent polymorphism of the coassembly structures, which originates from the terminal interactions of peptide with organic modulator moieties and can be attributed to the secondary structures of peptides and conformations of the organic molecules. Furthermore, the polymorphism of the peptide-organic coassemblies is shown to be correlated to distinctively different inhibition effects on amyloid-β 42 (Aβ42) aggregations and cytotoxicity.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Alzheimer's disease research and treatments · Chemical Synthesis and Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

Institute for Advanced Materials, Jiangsu University, Jiangsu 212013, China

State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), and Department of Physics, Fudan University, Shanghai 200433, China

Interdisciplinary Nanoscience Center (iNANO), Center for DNA Nanotechnology (CDNA), Aarhus University, DK-8000 Aarhus C, Denmark

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Sino-Danish Center for Education and Research

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