journal article·2014-07-22Open access

Multicolor and Erasable DNA Photolithography

Fujian Huang, Huaguo Xu, Weihong Tan, Haojun Liang

ACS Nano· Volume 8· Issue 7

Abstract

The immobilization of DNA molecules onto a solid support is a crucial step in biochip research and related applications. In this work, we report a DNA photolithography method based on photocleavage of 2-nitrobenzyl linker-modified DNA strands. These strands were subjected to ultraviolet light irradiation to generate multiple short DNA strands in a programmable manner. Coupling the toehold-mediated DNA strand-displacement reaction with DNA photolithography enabled the fabrication of a DNA chip surface with multifunctional DNA patterns having complex geometrical structures at the microscale level. The erasable DNA photolithography strategy was developed to allow different paintings on the same chip. Furthermore, the asymmetrical modification of colloidal particles was carried out by using this photolithography strategy. This strategy has broad applications in biosensors, nanodevices, and DNA-nanostructure fabrication.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanofabrication and Lithography Techniques · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China

Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Interface of Bio/Nano, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, United States

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, Hunan 410082, China

Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China

References (38)

Show source-provided references
1. Jayasena S. D. · Clin. Chem. · 1999 · 45 · 162810.1093/clinchem/45.9.1628 ↗
2. Storhoff J. J. · Nat. Biotechnol. · 2004 · 22 · 88310.1038/nbt977 ↗
3. Zhu G. Z. · Proc. Natl. Acad. Sci. U.S.A. · 2013 · 110 · 799810.1073/pnas.1220817110 ↗
4. Bagalkot V. · Nano Lett. · 2007 · 7 · 306510.1021/nl071546n ↗
5. Xiao Y. · Angew. Chem., Int. Ed. · 2005 · 44 · 545610.1002/anie.200500989 ↗
6. He L. · J. Am. Chem. Soc. · 2000 · 122 · 907110.1021/ja001215b ↗
7. Xiao Y. · J. Am. Chem. Soc. · 2005 · 127 · 1799010.1021/ja056555h ↗
8. Modi S. · Nat. Nanotechnol. · 2013 · 8 · 45910.1038/nnano.2013.92 ↗
9. Feldkamp U. · Angew. Chem., Int. Ed. · 2006 · 45 · 185610.1002/anie.200502358 ↗
10. Liu D. S. · J. Am. Chem. Soc. · 2006 · 128 · 206710.1021/ja0568300 ↗
11. Seeman N. C. · Annu. Rev. Biochem. · 2010 · 79 · 6510.1146/annurev-biochem-060308-102244 ↗
12. Bath J. · Nat. Nanotechnol. · 2007 · 2 · 27510.1038/nnano.2007.104 ↗
13. Yurke B. · Nature · 2000 · 406 · 60510.1038/35020524 ↗
14. Zhang D. Y. · Nat. Chem. · 2011 · 3 · 10310.1038/nchem.957 ↗
15. Song T. J. · J. Am. Chem. Soc. · 2012 · 134 · 1080310.1021/ja304746k ↗
16. Pavlov V. · J. Am. Chem. Soc. · 2004 · 126 · 1176810.1021/ja046970u ↗
17. Baker B. R. · J. Am. Chem. Soc. · 2006 · 128 · 313810.1021/ja056957p ↗
18. Khan M. N. · Angew. Chem., Int. Ed. · 2012 · 51 · 1030310.1002/anie.201204245 ↗
19. Pirrung M. C. · Angew. Chem., Int. Ed. · 2002 · 41 · 127610.1002/1521-3773(20020415)41:8<1276::AID-ANIE1276>3.0.CO;2-2 ↗
20. Samanta D. · Chem. Soc. Rev. · 2011 · 40 · 256710.1039/c0cs00056f ↗
21. Balamurugan S. · Anal. Bioanal. Chem. · 2008 · 390 · 100910.1007/s00216-007-1587-2 ↗
22. Xia D. · Small · 2012 · 8 · 278710.1002/smll.201200240 ↗
23. Fodor S. P. A. · Science · 1991 · 251 · 76710.1126/science.1990438 ↗
24. Pease A. C. · Proc. Natl. Acad. Sci. U.S.A. · 1994 · 91 · 502210.1073/pnas.91.11.5022 ↗
25. Chow B. Y. · Proc. Natl. Acad. Sci. U.S.A. · 2009 · 106 · 1521910.1073/pnas.0813011106 ↗
26. Zhou X. · Small · 2011 · 227310.1002/smll.201002381 ↗
27. Piner R. D. · Science · 1999 · 283 · 66110.1126/science.283.5402.661 ↗
28. Feng L. · Nat. Mater. · 2013 · 12 · 74710.1038/nmat3645 ↗
29. Huang F. J. · J. Am. Chem. Soc. · 2013 · 135 · 796710.1021/ja4018495 ↗
30. Seo T. S. · Proc. Natl. Acad. Sci. U.S.A. · 2005 · 102 · 592610.1073/pnas.0501965102 ↗
31. Ruparel H. · Proc. Natl. Acad. Sci. U.S.A. · 2005 · 102 · 593210.1073/pnas.0501962102 ↗
32. Qiu L. · J. Am. Chem. Soc. · 2013 · 135 · 1295210.1021/ja406252w ↗
33. Escorihuela J. · Chem. Commun. · 2012 · 48 · 211610.1039/c2cc17321b ↗
34. Chee M. · Science · 1996 · 274 · 61010.1126/science.274.5287.610 ↗
35. Liu Q. H. · Nature · 2000 · 403 · 17510.1038/35003155 ↗
36. Pregibon D. C. · Science · 2007 · 315 · 139310.1126/science.1134929 ↗
37. Jiang S. · Adv. Mater. · 2010 · 22 · 106010.1002/adma.200904094 ↗
38. Feng L. · Adv. Mater. · 2013 · 25 · 277910.1002/adma.201204864 ↗