Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling
Source abstract
Abstract
In recent years, the use of free-standing carbon nanotube (CNT) films for neural tissue engineering has attracted tremendous attention. CNT films show large surface area and high electrical conductivity that combined with flexibility and biocompatibility may promote neuron growth and differentiation while stimulating neural activity. In addition, adhesion, survival, and growth of neurons can be modulated through chemical modification of CNTs. Axonal and synaptic signaling can also be positively tuned by these materials. Here we describe the ability of free-standing CNT films to influence neuronal activity. We demonstrate that the degree of cross-linking between the CNTs has a strong impact on the electrical conductivity of the substrate, which, in turn, regulates neural circuit outputs.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Graphene and Nanomaterials Applications · Carbon Nanotubes in Composites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical and Pharmaceutical Sciences, Università degli Studi di Trieste, Via Licio Giorgieri 1, Trieste 34127, Italy
International School for Advanced Studies (SISSA/ISAS), Trieste 34136, Italy
Carbon Bionanotechnology Group, CIC biomaGUNE, Paseo Miramón 182, San Sebastián, Guipúzcoa 20014, Spain
Basque Foundation for Science, Ikerbasque, Bilbao 48013, Spain
Funding
AXA Research Fund · Ministero dell?Istruzione, dell?Universit? e della Ricerca · Ministerio de Econom?a y Competitividad · H2020 Future and Emerging Technologies · Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali
References (63)
Show source-provided references
1. 10.1038/nmat288510.1038/nmat2885 ↗
2. 10.1021/cr050569o10.1021/cr050569o ↗
3. 10.1021/cm020367y10.1021/cm020367y ↗
4. 10.1002/adma.20080106210.1002/adma.200801062 ↗
5. 10.1021/nl302327410.1021/nl3023274 ↗
6. 10.1039/C4RA12026D10.1039/C4RA12026D ↗
7. 10.1016/S1748-0132(08)70062-810.1016/S1748-0132(08)70062-8 ↗
8. 10.3390/ma902006810.3390/ma9020068 ↗
9. 10.1021/jacs.7b1291010.1021/jacs.7b12910 ↗
10. 10.1016/j.carbon.2003.12.01910.1016/j.carbon.2003.12.019 ↗
11. 10.1016/j.carbon.2009.11.01610.1016/j.carbon.2009.11.016 ↗
12. 10.1039/C5TA00163C10.1039/C5TA00163C ↗
13. 10.1021/ma800869w10.1021/ma800869w ↗
14. 10.1016/j.carbon.2017.03.07910.1016/j.carbon.2017.03.079 ↗
15. 10.1021/cr900296210.1021/cr9002962 ↗
16. 10.1126/science.aan122710.1126/science.aan1227 ↗
17. 10.1038/nnano.2008.37410.1038/nnano.2008.374 ↗
18. 10.1515/ntrev-2012-006710.1515/ntrev-2012-0067 ↗
19. 10.1166/jns.2009.00210.1166/jns.2009.002 ↗
20. 10.1021/nl301428w10.1021/nl301428w ↗
21. 10.1021/nl402226z10.1021/nl402226z ↗
22. 10.1126/sciadv.160008710.1126/sciadv.1600087 ↗
23. 10.1038/nnano.2008.17410.1038/nnano.2008.174 ↗
24. 10.1021/nn103445d10.1021/nn103445d ↗
25. 10.1016/j.carbon.2015.07.07410.1016/j.carbon.2015.07.074 ↗
26. 10.1021/jp044113710.1021/jp0441137 ↗
27. 10.1021/nl802855c10.1021/nl802855c ↗
28. 10.1088/0957-4484/22/19/19510110.1088/0957-4484/22/19/195101 ↗
29. 10.1002/adem.20090014410.1002/adem.200900144 ↗
30. 10.1021/nl035193d10.1021/nl035193d ↗
31. 10.1263/jbb.103.21610.1263/jbb.103.216 ↗
32. 10.1016/j.biomaterials.2011.04.05110.1016/j.biomaterials.2011.04.051 ↗
33. 10.1002/adma.20090088710.1002/adma.200900887 ↗
34. 10.1021/acsami.8b1646210.1021/acsami.8b16462 ↗
35. 10.1021/nl050637m10.1021/nl050637m ↗
36. 10.1038/srep0956210.1038/srep09562 ↗
37. 10.1088/0957-4484/21/23/23510210.1088/0957-4484/21/23/235102 ↗
38. 10.1021/cm010990310.1021/cm0109903 ↗
39. 10.1021/ja010462s10.1021/ja010462s ↗
40. 10.1021/acsami.8b2055710.1021/acsami.8b20557 ↗
41. 10.1055/s-2003-4498310.1055/s-2003-44983 ↗
42. 10.1039/C8SC03737J10.1039/C8SC03737J ↗
43. 10.1021/ja308969p10.1021/ja308969p ↗
44. van der Pauw L. J. · Phys. Technol. Rev. · 1958 · 20 · 220
45. 10.1523/JNEUROSCI.1332-11.201110.1523/JNEUROSCI.1332-11.2011 ↗
46. 10.1523/JNEUROSCI.06-03-00714.198610.1523/JNEUROSCI.06-03-00714.1986 ↗
47. 10.1016/S0014-5793(00)02359-010.1016/S0014-5793(00)02359-0 ↗
48. 10.1371/journal.pone.003464810.1371/journal.pone.0034648 ↗
49. 10.1038/nrn316810.1038/nrn3168 ↗
50. 10.1016/j.neuron.2012.02.01110.1016/j.neuron.2012.02.011 ↗
51. 10.1111/j.1469-7793.2000.t01-1-00639.x10.1111/j.1469-7793.2000.t01-1-00639.x ↗
52. 10.1021/acsnano.6b0013010.1021/acsnano.6b00130 ↗
53. 10.1371/journal.pcbi.100265310.1371/journal.pcbi.1002653 ↗
54. 10.1016/j.ceca.2006.07.00610.1016/j.ceca.2006.07.006 ↗
55. 10.1016/S0028-3908(00)00095-210.1016/S0028-3908(00)00095-2 ↗
56. 10.3389/fncir.2013.0019910.3389/fncir.2013.00199 ↗
57. 10.1523/JNEUROSCI.1051-07.200710.1523/JNEUROSCI.1051-07.2007 ↗
58. 10.1073/pnas.94.17.894810.1073/pnas.94.17.8948 ↗
59. 10.1242/dev.0035110.1242/dev.00351 ↗
60. 10.1016/j.celrep.2015.04.00210.1016/j.celrep.2015.04.002 ↗
61. 10.1017/S003358350100374210.1017/S0033583501003742 ↗
62. 10.3389/fncel.2014.0025810.3389/fncel.2014.00258 ↗
63. 10.1038/s41598-017-11359-x10.1038/s41598-017-11359-x ↗