Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer
Source abstract
Abstract
The generation of nanosized probes often requires time-intensive and application-specific optimization processes that involve conjugating a nanoconstruct to a targeting moiety. Herein, we genetically modify apoferritin and generate a universal interface system composed of protein G and 6×His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Quantum Dots Synthesis And Properties · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), 5 Hwarangno 14-gil, Seongbuk-gu, Seoul 136-791, Republic of Korea
Advanced Analysis Center, Korea Institute of Science and Technology (KIST), 5 Hwarangno 14-gil, Seongbuk-gu, Seoul 136-791, Republic of Korea
References (36)
Show source-provided references
1. Adler-Abramovich L. · Angew. Chem., Int. Ed. · 2010 · 49 · 993910.1002/anie.201002037 ↗
2. Saleh N. · Nano Lett. · 2005 · 5 · 248910.1021/nl0518268 ↗
3. Honda K. · Cancer Res. · 2005 · 65 · 1061310.1158/0008-5472.CAN-05-1851 ↗
4. Patterson S. D. · Nat. Genet. · 2003 · 33 · 31110.1038/ng1106 ↗
5. Yee J. · J. Clin. Oncol. · 2009 · 27 · 278710.1200/JCO.2008.19.4233 ↗
6. Zhu W. · Proc. Natl. Acad. Sci. U.S.A. · 2003 · 100 · 1466610.1073/pnas.2532248100 ↗
7. Wei F. · Anal. Bioanal. Chem. · 2009 · 393 · 194310.1007/s00216-009-2687-y ↗
8. Chah S. · Chem. Biol. · 2005 · 12 · 32310.1016/j.chembiol.2005.01.013 ↗
9. Sandros M. G. · J. Am. Chem. Soc. · 2005 · 127 · 1219810.1021/ja054166h ↗
10. Arosio P. · Biochim. Biophys. Acta · 2009 · 1790 · 58910.1016/j.bbagen.2008.09.004 ↗
11. Guss B. · EMBO J. · 1986 · 5 · 156710.1002/j.1460-2075.1986.tb04398.x ↗
12. Paborsky L. R. · Anal. Biochem. · 1996 · 234 · 6010.1006/abio.1996.0050 ↗
13. Hruban R. H. · Int. J. Clin. Exp. Pathol. · 2008 · 1 · 306
14. Caskey J. H. · Proc. Natl. Acad. Sci. U.S.A. · 1983 · 80 · 48210.1073/pnas.80.2.482 ↗
15. Worwood M. · Hum. Genet. · 1985 · 69 · 37110.1007/BF00291657 ↗
16. Derrick J. P. · Nature · 1992 · 359 · 75210.1038/359752a0 ↗
17. Hainfeld J. F. · J. Struct. Biol. · 1999 · 127 · 18510.1006/jsbi.1999.4149 ↗
18. Kato K. · Structure · 1995 · 3 · 7910.1016/S0969-2126(01)00136-8 ↗
19. Sauer-Eriksson A. E. · Structure · 1995 · 3 · 26510.1016/S0969-2126(01)00157-5 ↗
20. Saha K. · Anal. Chem. · 2003 · 75 · 83510.1021/ac0204911 ↗
21. Schmitt J. · Mol. Biol. Rep. · 1993 · 18 · 22310.1007/BF01674434 ↗
22. Medintz I. L. · Nat. Mater. · 2005 · 4 · 43510.1038/nmat1390 ↗
23. Michalet X. · Science · 2005 · 307 · 53810.1126/science.1104274 ↗
24. Lee K. H. · Nanomedicine · 2012 · 8 · 104310.1016/j.nano.2012.01.005 ↗
25. Park H. · Nanoscale · 2013 · 5 · 860910.1039/c3nr02357e ↗
26. Nichols L. S. · Am. J. Clin. Pathol. · 2004 · 121 · 22610.1309/K144PHVDDUPDD401 ↗
27. Conti M. · Angew. Chem., Int. Ed. · 2000 · 39 · 21510.1002/(SICI)1521-3773(20000103)39:1<215::AID-ANIE215>3.0.CO;2-R ↗
28. Park H. · Nanotechnology · 2013 · 24 · 28510310.1088/0957-4484/24/28/285103 ↗
29. Leatherdale C. A. · J. Phys. Chem. B · 2002 · 106 · 761910.1021/jp025698c ↗
30. Chevalier S. B. · Langmuir · 2010 · 26 · 1470710.1021/la103086b ↗
31. Lin X. · Angew. Chem., Int. Ed. · 2011 · 50 · 156910.1002/anie.201006757 ↗
32. Lawson D. M. · FEBS Lett. · 1989 · 254 · 20710.1016/0014-5793(89)81040-3 ↗
33. Torti F. M. · Blood · 2002 · 99 · 350510.1182/blood.V99.10.3505 ↗
34. Aime S. · Angew. Chem., Int. Ed. · 2002 · 41 · 101710.1002/1521-3773(20020315)41:6<1017::AID-ANIE1017>3.0.CO;2-P ↗
35. Fan K. · Nat. Nanotechnol. · 2012 · 7 · 45910.1038/nnano.2012.90 ↗
36. Ma-Ham A. · J. Mater. Chem. · 2011 · 21 · 870010.1039/c0jm04321d ↗