journal article·2019-06-25

Toxicological Risk Assessments of Iron Oxide Nanocluster- and Gadolinium-Based T1MRI Contrast Agents in Renal Failure Rats

Qinjie Weng, Xi Hu, Jiahuan Zheng, Fan Xia, Nan Wang, Hongwei Liao, Ying Liu, Dokyoon Kim, Jianan Liu, Fangyuan Li, Qiaojun He, Bo Yang, Chunying Chen, Taeghwan Hyeon, Daishun Ling

ACS Nano· Volume 13· Issue 6
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Abstract

Gadolinium-based contrast agents (GBCAs) are widely used for T1-weighted magnetic resonance imaging (MRI) in clinic diagnosis. However, a major drawback of GBCAs is that they can increase the toxicological risk of nephrogenic systemic fibrosis (NSF) in patients with advanced renal dysfunction. Hence, safer alternatives to GBCAs are currently in demand, especially for patients with renal diseases. Here we investigated the potential of polyethylene glycol (PEG)-stabilized iron oxide nanoclusters (IONCs) as biocompatible T1MRI contrast agents and systematically evaluated their NSF-related risk in rats with renal failure. We profiled the distribution, excretion, histopathological alterations, and fibrotic gene expressions after administration of IONCs and GBCAs. Our results showed that, compared with GBCAs, IONCs exhibited dramatically improved biosafety and a much lower risk of causing NSF, suggesting the feasibility of substituting GBCAs with IONCs in clinical MRI diagnosis of patients with renal diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Lanthanide and Transition Metal Complexes · Radioactive element chemistry and processing · Carbon and Quantum Dots Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Center for Drug Safety Evaluation and Research, Zhejiang University, Hangzhou 310058, China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China and University of Chinese Academy of Sciences, Beijing 100190, China

Department of Bionano Engineering, Hanyang University, Ansan 15588, Korea

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Korea

School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea

Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310058, China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Institute of Basic Science · Zhejiang Province

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