Engineering Programmed Death Ligand-1/Cytotoxic T-Lymphocyte-Associated Antigen-4 Dual-Targeting Nanovesicles for Immunosuppressive Therapy in Transplantation
Source abstract
Abstract
T cells and cytokine production, enriched regulatory T cells, and prolonged the survival of mouse skin and heart grafts. Taken together, these data supported the idea that PD-L1/CTLA-4 dual-targeting NVs exert immune inhibitory effects and may be used as a prospective immunosuppressant in organ transplantation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Extracellular vesicles in disease · Immunotherapy and Immune Responses · Immune Cell Function and Interaction
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, 518107, Shenzhen, China
Funding
Sun Yat-sen University · Sigrid Jus?liuksen S??ti? · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Science, Technology and Innovation Commission of Shenzhen Municipality
References (36)
Show source-provided references
1. 10.1080/14737159.2016.123953010.1080/14737159.2016.1239530 ↗
2. 10.1016/j.transci.2017.07.00510.1016/j.transci.2017.07.005 ↗
3. 10.1038/nm125110.1038/nm1251 ↗
4. 10.1038/nm0611-66210.1038/nm0611-662 ↗
5. 10.2215/CJN.0857081410.2215/CJN.08570814 ↗
6. 10.1016/j.anclin.2017.04.00110.1016/j.anclin.2017.04.001 ↗
7. 10.1016/j.jpba.2016.01.05910.1016/j.jpba.2016.01.059 ↗
8. 10.1186/s13045-018-0582-810.1186/s13045-018-0582-8 ↗
9. 10.1016/j.ccell.2017.05.01010.1016/j.ccell.2017.05.010 ↗
10. 10.1159/00043717810.1159/000437178 ↗
11. Hayashi H. · Int. J. Clin Oncol · 2019
12. 10.1056/NEJMoa100346610.1056/NEJMoa1003466 ↗
13. Voena C. · Discov Med. · 2016 · 21 · 125
14. 10.1016/S1470-2045(09)70334-110.1016/S1470-2045(09)70334-1 ↗
15. 10.1158/0008-5472.CAN-16-164710.1158/0008-5472.CAN-16-1647 ↗
16. 10.1097/01.tp.0000256293.90270.e810.1097/01.tp.0000256293.90270.e8 ↗
17. 10.1126/scitranslmed.aad711810.1126/scitranslmed.aad7118 ↗
18. 10.4049/jimmunol.169.11.654610.4049/jimmunol.169.11.6546 ↗
19. 10.1016/j.jaut.2013.06.00610.1016/j.jaut.2013.06.006 ↗
20. 10.1056/NEJMoa150602710.1056/NEJMoa1506027 ↗
21. 10.1038/nrd397810.1038/nrd3978 ↗
22. 10.1172/JCI8113110.1172/JCI81131 ↗
23. 10.1016/j.nantod.2016.10.00810.1016/j.nantod.2016.10.008 ↗
24. 10.1002/adma.20187015210.1002/adma.201870152 ↗
25. 10.1021/acs.nanolett.8b0232110.1021/acs.nanolett.8b02321 ↗
26. 10.1038/s41573-019-0028-110.1038/s41573-019-0028-1 ↗
27. 10.1093/labmed/lmx05610.1093/labmed/lmx056 ↗
28. 10.1097/TP.000000000000143610.1097/TP.0000000000001436 ↗
29. 10.1111/ajt.1508310.1111/ajt.15083 ↗
30. 10.3389/fimmu.2019.0085610.3389/fimmu.2019.00856 ↗
31. 10.1080/21691401.2019.166961710.1080/21691401.2019.1669617 ↗
32. 10.1080/17460441.2018.153558910.1080/17460441.2018.1535589 ↗
33. 10.1056/NEJMoa170968410.1056/NEJMoa1709684 ↗
34. 10.1016/j.molmed.2019.02.00310.1016/j.molmed.2019.02.003 ↗
35. 10.1021/acs.nanolett.7b0526310.1021/acs.nanolett.7b05263 ↗
36. 10.3791/5344210.3791/53442 ↗