journal article·2016-05-24Open access

Self-Assembled Core–Satellite Gold Nanoparticle Networks for Ultrasensitive Detection of Chiral Molecules by Recognition Tunneling Current

Yuanchao Zhang, Jingquan Liu, Da Li, Xing Dai, Fuhua Yan, Xavier A. Conlan, Ruhong Zhou, Colin J. Barrow, Jin He, Xin Wang, Wenrong Yang

ACS Nano· Volume 10· Issue 5

Abstract

Chirality sensing is a very challenging task. Here, we report a method for ultrasensitive detection of chiral molecule l/d-carnitine based on changes in the recognition tunneling current across self-assembled core-satellite gold nanoparticle (GNP) networks. The recognition tunneling technique has been demonstrated to work at the single molecule level where the binding between the reader molecules and the analytes in a nanojunction. This process was observed to generate a unique and sensitive change in tunneling current, which can be used to identify the analytes of interest. The molecular recognition mechanism between amino acid l-cysteine and l/d-carnitine has been studied with the aid of SERS. The different binding strength between homo- or heterochiral pairs can be effectively probed by the copper ion replacement fracture. The device resistance was measured before and after the sequential exposures to l/d-carnitine and copper ions. The normalized resistance change was found to be extremely sensitive to the chirality of carnitine molecule. The results suggested that a GNP networks device optimized for recognition tunneling was successfully built and that such a device can be used for ultrasensitive detection of chiral molecules.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanocluster Synthesis and Applications · Gold and Silver Nanoparticles Synthesis and Applications · Electrochemical Analysis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China

School of Life and Environmental Science, Centre for Chemistry and Biotechnology, Deakin University, Geelong, Victoria 3216, Australia

College of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China

School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China

Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China

IBM Thomas J. Watson Research Centre, Yorktown Heights, New York 10598, United States

Physics Department, Biomolecular Science Institute, Florida International University, Miami, Florida 33199, United States

Funding

Deakin University · Australian Research Council · Division of Civil, Mechanical and Manufacturing Innovation · China Scholarship Council

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