DataVXACS NanoPaper
journal article·2017-06-27Open access

Sensing by Smell: Nanoparticle–Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output

Bradley Duncan, Ngoc D. B. Le, Colleen Alexander, Akash Gupta, Gulen Yesilbag Tonga, Mahdieh Yazdani, Ryan F. Landis, Li-Sheng Wang, Bo Yan, Serdar Burmaoglu, Xiaoning Li, Vincent M. Rotello

ACS Nano· Volume 11· Issue 6
Publisher pageOpen full text
Source abstract

Abstract

We present here a highly efficient sensor for bacteria that provides an olfactory output, allowing detection without the use of instrumentation and with a modality that does not require visual identification. The sensor platform uses nanoparticles to reversibly complex and inhibits lipase. These complexes are disrupted in the presence of bacteria, restoring enzyme activity and generating scent from odorless pro-fragrance substrate molecules. This system provides rapid (15 min) sensing and very high sensitivity (10 2 cfu/mL) detection of bacteria using the human sense of smell as an output.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Chemical Sensor Technologies · Olfactory and Sensory Function Studies · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States

Tercan Vocational High School, Erzincan University, 24800 Tercan, Erzincan, Turkey

Funding

U.S. Department of State · National Academies of Sciences, Engineering, and Medicine · Higher Education Commission, Pakistan · National Institute of General Medical Sciences · United States Agency for International Development · Ministry of Science and Technology of Pakistan · Manning Fund, University of Massachusetts · Firmenich SA

References (34)

Show source-provided references
1. 10.1007/s00221-010-2348-610.1007/s00221-010-2348-6 ↗
2. 10.1126/science.124916810.1126/science.1249168 ↗
3. 10.1002/anie.20130880810.1002/anie.201308808 ↗
4. 10.1039/C5PY00944H10.1039/C5PY00944H ↗
5. 10.1039/C4RA07728H10.1039/C4RA07728H ↗
6. 10.1002/anie.20130968410.1002/anie.201309684 ↗
7. 10.1002/anie.20120700810.1002/anie.201207008 ↗
8. 10.1002/anie.20141088410.1002/anie.201410884 ↗
9. 10.1126/science.277.5329.107810.1126/science.277.5329.1078 ↗
10. 10.1038/nnano.2012.18610.1038/nnano.2012.186 ↗
11. 10.1021/ja100675610.1021/ja1006756 ↗
12. 10.1039/C4CS00387J10.1039/C4CS00387J ↗
13. 10.1021/ja202172910.1021/ja2021729 ↗
14. 10.1002/smll.20140175310.1002/smll.201401753 ↗
15. WHO, UNICEF (2014) Progress on Drinking Water and Sanitation: 2014 Update;WHO Press,Geneva, Switzerland.
16. WHO (2011) Guidelines for Drinking-Water Quality,4th ed.WHO Press,Geneva, Switzerland.
17. 10.1021/ja202172910.1021/ja2021729 ↗
18. 10.1002/anie.20070026410.1002/anie.200700264 ↗
19. 10.1016/j.bios.2012.03.00610.1016/j.bios.2012.03.006 ↗
20. 10.1021/ac301904x10.1021/ac301904x ↗
21. 10.1039/c3nr00141e10.1039/c3nr00141e ↗
22. 10.1016/j.ijfoodmicro.2003.08.00510.1016/j.ijfoodmicro.2003.08.005 ↗
23. 10.1021/nn504262510.1021/nn5042625 ↗
24. 10.1039/C5CS00041F10.1039/C5CS00041F ↗
25. 10.1039/c1cc14448k10.1039/c1cc14448k ↗
26. 10.1038/nnano.2014.28510.1038/nnano.2014.285 ↗
27. 10.1021/acscentsci.5b0012610.1021/acscentsci.5b00126 ↗
28. 10.1093/chemse/28.1.2510.1093/chemse/28.1.25 ↗
29. 10.1016/j.molimm.2007.09.00410.1016/j.molimm.2007.09.004 ↗
30. Poole C. F. · 2012
31. 10.1017/S002221510700097710.1017/S0022215107000977 ↗
32. 10.1038/nchem.228410.1038/nchem.2284 ↗
33. McDonald J. H. · 2009
34. Miller J. C. · 1984