journal article·2013-11-26

Near-Infrared Fluorescence Energy Transfer Imaging of Nanoparticle Accumulation and Dissociation Kinetics in Tumor-Bearing Mice

Yiming Zhao, Inge van Rooy, Sjoerd Hak, Francois Fay, Jun Tang, Catharina de Lange Davies, Mihaela Skobe, Edward Allen Fisher, Aurelian Radu, Zahi. A. Fayad, Celso de Mello Donegá, Andries Meijerink, Willem J. M. Mulder

ACS Nano· Volume 7· Issue 11
Publisher page

Abstract

In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Condensed Matter and Interfaces, Debye Institute for Nanomaterials Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, United States

Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, United States

MI Lab and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway

Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, United States

Department of Physics, The Norwegian University of Science and Technology, Trondheim, Norway

Derald H. Ruttenberg Cancer Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, United States

Langone Medical Center, New York University, New York, United States

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

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