Optical Interference-Free Surface-Enhanced Raman Scattering CO-Nanotags for Logical Multiplex Detection of Vascular Disease-Related Biomarkers
Source abstract
Abstract
Matrix metalloproteinases (MMPs), specifically MMP-2, MMP-7, and MMP-9, have been discovered to be linked to many forms of vascular diseases such as stroke, and their detection is crucial to facilitate clinical diagnosis. In this work, we prepared a class of optical interference-free SERS nanotags (CO-nanotags) that can be used for the purpose of multiplex sensing of different MMPs. Multiplex detection with the absence of cross-talk was achieved by using CO-nanotags with individual tunable intrinsic Raman shifts of CO in the 1800–2200 cm –1 region determined by the metal core and ligands of the metal carbonyl complex. Boolean logic was used as well to simultaneously probe for two proteolytic inputs. Such nanotags offer the advantages of convenient detection of target nanotags and high sensitivity as validated in the ischemia rat model.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Gold and Silver Nanoparticles Synthesis and Applications · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, P. R. China
Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan
Sustainable Energy Development Center, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyen Road, Zhunan, Miaoli Country, 35053, Taiwan
Funding
National Health Research Institutes · Ministry of Science and Technology, Taiwan
References (52)
Show source-provided references
1. 10.1056/NEJMe150321710.1056/NEJMe1503217 ↗
2. 10.1056/NEJMp151469610.1056/NEJMp1514696 ↗
3. 10.1038/sj.onc.120718110.1038/sj.onc.1207181 ↗
4. Xu X. · Cancer Res. · 2005 · 65 · 13010.1158/0008-5472.130.65.1 ↗
5. 10.1038/nrc74510.1038/nrc745 ↗
6. 10.1038/nrn110610.1038/nrn1106 ↗
7. 10.3109/00207454.2013.87210210.3109/00207454.2013.872102 ↗
8. 10.1371/journal.pone.008493510.1371/journal.pone.0084935 ↗
9. 10.1038/nmat216210.1038/nmat2162 ↗
10. 10.1002/anie.20120574810.1002/anie.201205748 ↗
11. 10.1002/anie.20090646210.1002/anie.200906462 ↗
12. 10.1021/jacs.5b0142610.1021/jacs.5b01426 ↗
13. 10.1002/anie.20150502510.1002/anie.201505025 ↗
14. 10.1002/anie.20120434910.1002/anie.201204349 ↗
15. 10.1016/j.bios.2013.10.05210.1016/j.bios.2013.10.052 ↗
16. 10.1021/ja409230g10.1021/ja409230g ↗
17. Jaouen G. · 2006
18. 10.1006/abio.1993.101510.1006/abio.1993.1015 ↗
19. 10.1021/tx900056a10.1021/tx900056a ↗
20. 10.1002/cmdc.20080006910.1002/cmdc.200800069 ↗
21. 10.1021/bc070133a10.1021/bc070133a ↗
22. 10.1002/anie.20030163410.1002/anie.200301634 ↗
23. 10.1039/b701992k10.1039/b701992k ↗
24. 10.1039/b002585m10.1039/b002585m ↗
25. 10.1016/j.jorganchem.2005.03.06510.1016/j.jorganchem.2005.03.065 ↗
26. 10.1021/ja00083a02410.1021/ja00083a024 ↗
27. 10.1021/ic010516z10.1021/ic010516z ↗
28. 10.1039/C5SC02971F10.1039/C5SC02971F ↗
29. 10.1021/cr60307a00210.1021/cr60307a002 ↗
30. 10.1002/adma.20110349610.1002/adma.201103496 ↗
31. 10.1021/nn401199k10.1021/nn401199k ↗
32. 10.1021/ja200247x10.1021/ja200247x ↗
33. 10.1021/nn203851610.1021/nn2038516 ↗
34. 10.1161/01.STR.0000244808.17972.5510.1161/01.STR.0000244808.17972.55 ↗
35. Binder S. · 2013 · 14910.1016/B978-0-08-097037-0.00011-7 ↗
36. 10.2174/15701590979003115710.2174/157015909790031157 ↗
37. 10.1016/j.bios.2013.03.03010.1016/j.bios.2013.03.030 ↗
38. 10.1155/2014/82030410.1155/2014/820304 ↗
39. 10.3109/00207454.2013.87210210.3109/00207454.2013.872102 ↗
40. 10.1021/ac501656310.1021/ac5016563 ↗
41. 10.1021/ac202627b10.1021/ac202627b ↗
42. 10.1021/acs.analchem.5b0252910.1021/acs.analchem.5b02529 ↗
43. 10.1039/C6CC00928J10.1039/C6CC00928J ↗
44. 10.1039/C2AN36128K10.1039/C2AN36128K ↗
45. 10.1364/BOE.6.00207610.1364/BOE.6.002076 ↗
46. 10.1161/01.STR.29.5.102010.1161/01.STR.29.5.1020 ↗
47. 10.1038/srep1695110.1038/srep16951 ↗
48. 10.1021/ic50066a00710.1021/ic50066a007 ↗
49. 10.1080/0095897960802270010.1080/00958979608022700 ↗
50. 10.1016/S0022-328X(00)89480-210.1016/S0022-328X(00)89480-2 ↗
51. 10.1016/S0022-328X(97)00760-210.1016/S0022-328X(97)00760-2 ↗
52. 10.1021/jp510073y10.1021/jp510073y ↗