Nano-Jewels in Biology. Gold and Platinum on Diamond Nanoparticles as Antioxidant Systems Against Cellular Oxidative Stress
Source abstract
Abstract
Diamond nanoparticles (DNPs) obtained by explosive detonation have become commercially available. These commercial DNPs can be treated under Fenton conditions (FeSO(4) and H(2)O(2) at acidic pH) to obtain purer DNP samples with a small average particle size (4 nm) and a large population of surface OH groups (HO-DNPs). These Fenton-treated HO-DNPs have been used as a support of gold and platinum nanoparticles (≤2 nm average size). The resulting materials (Au/HO-DNP and Pt/HO-DNP) exhibit a high antioxidant activity against reactive oxygen species induced in a hepatoma cell line. In addition to presenting good biocompatibility, Au/HO- and Pt/HO-DNP exhibit about a two-fold higher antioxidant activity than glutathione, one of the reference antioxidant systems. The most active material against cellular oxidative stress was Au/HO-DNP.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticles: synthesis and applications · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Instituto de Tecnología Química CSIC-UPV and Departamento de Química, Universidad Politécnica de Valencia, Av. De los Naranjos s/n, 46022 Valencia, Spain
Institut d’Alta Tecnologia-PRBB, c/Dr. Aiguader 88, 08003 Barcelona, Spain
Department of Pharmacology, University of Valencia and CIBERehd, Valencia, Spain
University Hospital Doctor Peset Foundation and CIBERehd, Avda Gaspar Aguilar 90, 46017, Valencia, Spain
University Hospital Doctor Peset, Endocrinology Service, Avda Gaspar Aguilar 90, 46017, Valencia, Spain
Department of Physiology, University of Valencia, Valencia, Spain
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